Gene table of IFIH1 : interferon induced with helicase C domain 1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with IFIH1	OMIM link	Number of associated genes	genes
PS182250	SINGLETON-MERTEN SYNDROME	ClinVar, OMIM, HUMSAVAR	link to OMIM	2	IFIH1, DDX58
PS225750	AICARDI-GOUTIERES SYNDROME	ClinVar, OMIM, HUMSAVAR	link to OMIM	7	IFIH1, RNASEH2B, RNASEH2C, RNASEH2A, ADAR, TREX1, SAMHD1

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Influenza A	hsa05164	5.21
Measles	hsa05162	5.6
Herpes simplex infection	hsa05168	5.08
Hepatitis B	hsa05161	5.52
RIG-I-like receptor signaling pathway	hsa04622	6.62

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
TRAF6 mediated NF-kB activation	R-HSA-933542	8.4
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	R-HSA-933543	9.4
TRAF6 mediated IRF7 activation	R-HSA-933541	7.98
TRAF3-dependent IRF activation pathway	R-HSA-918233	9.18
Innate Immune System	R-HSA-168249	3.17
Immune System	R-HSA-168256	2.37
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	R-HSA-168928	6.7
Negative regulators of RIG-I/MDA5 signaling	R-HSA-936440	7.98

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
macromolecular complex binding	GO:0044877	2.61
zinc ion binding	GO:0008270	2.66
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
transition metal ion binding	GO:0046914	2.48
single-stranded RNA binding	GO:0003727	5.5
ion binding	GO:0043167	1.36
nucleoside phosphate binding	GO:1901265	1.96
ribonucleoside binding	GO:0032549	2.22
ribonucleoprotein complex binding	GO:0043021	5.15
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
ATP binding	GO:0005524	2.43
hydrolase activity	GO:0016787	1.9
nucleoside-triphosphatase activity	GO:0017111	3.09
helicase activity	GO:0004386	4.69
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO:0016818	3.03
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
hydrolase activity, acting on acid anhydrides	GO:0016817	3.03
pyrophosphatase activity	GO:0016462	3.04
double-stranded RNA binding	GO:0003725	5.58
adenyl ribonucleotide binding	GO:0032559	2.41
RNA binding	GO:0003723	2.36
protein binding	GO:0005515	0.46
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
binding	GO:0005488	0.18