Gene table of IGF1R : insulin like growth factor 1 receptor

Gene-disease associations table

Disease ID	Disease name	Source of annotation with IGF1R	OMIM link	Number of associated genes	genes
270450	INSULIN-LIKE GROWTH FACTOR I, RESISTANCE TO	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	IGF1R

Download the gene annotation in CSV format

Annotation of the gene IGF1R

Associated genes in ENSEMBL

ENSG00000140443

Associated proteins - SwissProt Accession ID

P08069

Associated PDB IDs

Cytogenetic Band

15q26.3

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Melanoma	hsa05218	6.56
Oocyte meiosis	hsa04114	5.91
FoxO signaling pathway	hsa04068	5.63
Focal adhesion	hsa04510	4.92
Proteoglycans in cancer	hsa05205	5.02
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6
Ras signaling pathway	hsa04014	4.9
Pathways in cancer	hsa05200	3.98
Glioma	hsa05214	6.66
Prostate cancer	hsa05215	6.11
Ovarian steroidogenesis	hsa04913	7.07
Rap1 signaling pathway	hsa04015	4.97
Adherens junction	hsa04520	6.26
Endocytosis	hsa04144	4.92
Progesterone-mediated oocyte maturation	hsa04914	6.18
HIF-1 signaling pathway	hsa04066	5.9
Transcriptional misregulation in cancer	hsa05202	5.21
AMPK signaling pathway	hsa04152	5.8
Long-term depression	hsa04730	6.74
PI3K-Akt signaling pathway	hsa04151	4.21

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85
IGF1R signaling cascade	R-HSA-2428924	4.85
SHC-related events triggered by IGF1R	R-HSA-2428933	9.81
Signal Transduction	R-HSA-162582	1.78
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85

Associated GO terms for Molecular function

GO term	GO ID	GO IC
peptide hormone binding	GO:0017046	6.13
signaling receptor activity	GO:0038023	2.49
purine ribonucleoside triphosphate binding	GO:0035639	2.22
growth factor binding	GO:0019838	4.89
molecular transducer activity	GO:0060089	2.32
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
insulin receptor substrate binding	GO:0043560	7.25
phosphatidylinositol 3-kinase binding	GO:0043548	6.41
transferase activity	GO:0016740	1.95
nucleotide binding	GO:0000166	1.96
transmembrane receptor protein tyrosine kinase activity	GO:0004714	5.55
identical protein binding	GO:0042802	2.63
purine nucleoside binding	GO:0001883	2.22
protein kinase activity	GO:0004672	3.27
protein complex binding	GO:0032403	3.09
purine nucleotide binding	GO:0017076	2.19
insulin-like growth factor binding	GO:0005520	6.37
ATP binding	GO:0005524	2.43
protein tyrosine kinase activity	GO:0004713	4.54
kinase activity	GO:0016301	2.93
amide binding	GO:0033218	4.14
insulin receptor binding	GO:0005158	6.27
ribonucleoside binding	GO:0032549	2.22
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
insulin-like growth factor-activated receptor activity	GO:0005010	8.64
peptide binding	GO:0042277	4.22
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
hormone binding	GO:0042562	5.53
insulin-like growth factor I binding	GO:0031994	7.25
adenyl nucleotide binding	GO:0030554	2.4
insulin binding	GO:0043559	8.13
organic cyclic compound binding	GO:0097159	1.05
carbohydrate derivative binding	GO:0097367	2.03
transmembrane signaling receptor activity	GO:0004888	2.57
adenyl ribonucleotide binding	GO:0032559	2.41
transmembrane receptor activity	GO:0099600	2.53
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
receptor binding	GO:0005102	2.43
transmembrane receptor protein kinase activity	GO:0019199	5.32
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
receptor activity	GO:0004872	2.32