| Disease ID | Disease name | Source of annotation with IGF2 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 616489 | GROWTH RESTRICTION, SEVERE, WITH DISTINCTIVE FACIES | ClinVar, OMIM | link to OMIM | 1 | IGF2 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Proteoglycans in cancer | hsa05205 | 5.02 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | R-HSA-381426 | 8.59 |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 4.85 |
| Platelet degranulation | R-HSA-114608 | 6.68 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 5.15 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 6.59 |
| Metabolism of proteins | R-HSA-392499 | 3.41 |
| IGF1R signaling cascade | R-HSA-2428924 | 4.85 |
| IRS-related events triggered by IGF1R | R-HSA-2428928 | 4.85 |
| SHC-related events triggered by IGF1R | R-HSA-2428933 | 9.81 |
| Hemostasis | R-HSA-109582 | 3.98 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| hormone activity | GO:0005179 | 4.95 |
| insulin receptor binding | GO:0005158 | 6.27 |
| growth factor activity | GO:0008083 | 4.66 |
| protein kinase regulator activity | GO:0019887 | 4.6 |
| receptor regulator activity | GO:0030545 | 5.91 |
| enzyme regulator activity | GO:0030234 | 2.85 |
| kinase activator activity | GO:0019209 | 5.58 |
| receptor activator activity | GO:0030546 | 6.27 |
| protein complex binding | GO:0032403 | 3.09 |
| kinase regulator activity | GO:0019207 | 4.5 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| insulin-like growth factor receptor binding | GO:0005159 | 7.03 |
| receptor binding | GO:0005102 | 2.43 |
| molecular function regulator | GO:0098772 | 2.51 |
| protein kinase activator activity | GO:0030295 | 5.68 |
| protein serine/threonine kinase activator activity | GO:0043539 | 6.91 |
| enzyme activator activity | GO:0008047 | 3.56 |