Gene table of IKBKB : inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

Gene-disease associations table

Disease IDDisease nameSource of annotation with IKBKBOMIM linkNumber of associated genesgenes

Download the gene annotation in CSV format

Annotation of the gene IKBKB

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways
Pancreatic cancerhsa052126.56
Chronic myeloid leukemiahsa052206.48
Prostate cancerhsa052156.11
Pathways in cancerhsa052003.98
Neurotrophin signaling pathwayhsa047225.78
FoxO signaling pathwayhsa040685.63
Osteoclast differentiationhsa043805.64
NF-kappa B signaling pathwayhsa040646.21
Chemokine signaling pathwayhsa040625.19
Adipocytokine signaling pathwayhsa049206.6
Chagas disease (American trypanosomiasis)hsa051425.99
Herpes simplex infectionhsa051685.08
Epstein-Barr virus infectionhsa051694.97
Influenza Ahsa051645.21
HTLV-I infectionhsa051664.59
Hepatitis Chsa051605.68
Hepatitis Bhsa051615.52
Epithelial cell signaling in Helicobacter pylori infectionhsa051206.58
MicroRNAs in cancerhsa052065.38
Toll-like receptor signaling pathwayhsa046206.0
NOD-like receptor signaling pathwayhsa046216.88
RIG-I-like receptor signaling pathwayhsa046226.62
Cytosolic DNA-sensing pathwayhsa046236.79
T cell receptor signaling pathwayhsa046606.01
Insulin signaling pathwayhsa049105.55
Ras signaling pathwayhsa040144.9
Small cell lung cancerhsa052226.17
Acute myeloid leukemiahsa052216.74
MAPK signaling pathwayhsa040104.63
TNF signaling pathwayhsa046685.96
Type II diabetes mellitushsa049307.12
mTOR signaling pathwayhsa041506.72
PI3K-Akt signaling pathwayhsa041514.21
B cell receptor signaling pathwayhsa046626.52
Non-alcoholic fatty liver disease (NAFLD)hsa049325.51
Associated REACTOME pathways
TRIF-mediated TLR3/TLR4 signaling R-HSA-9370616.47
C-type lectin receptors (CLRs)R-HSA-56214816.06
Signaling by InterleukinsR-HSA-4491474.71
IKK complex recruitment mediated by RIP1R-HSA-9370418.46
Toll Like Receptor 2 (TLR2) CascadeR-HSA-1814386.51
Immune SystemR-HSA-1682562.37
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
MyD88 cascade initiated on plasma membraneR-HSA-9758716.73
Cytokine Signaling in Immune systemR-HSA-12802153.74
Diseases associated with the TLR signaling cascadeR-HSA-56023588.34
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysR-HSA-1689286.7
p75 NTR receptor-mediated signallingR-HSA-1937046.59
Innate Immune SystemR-HSA-1682493.17
Adaptive Immune SystemR-HSA-12802183.19
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulationR-HSA-9751449.18
IRAK1 recruits IKK complexR-HSA-9370399.18
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)R-HSA-56030279.98
Signalling by NGFR-HSA-1665204.23
IkBA variant leads to EDA-IDR-HSA-560302910.18
Toll Like Receptor 3 (TLR3) CascadeR-HSA-1681646.47
MyD88 dependent cascade initiated on endosomeR-HSA-9751556.68
Toll-Like Receptors CascadesR-HSA-1688985.91
p75NTR recruits signalling complexesR-HSA-2095439.28
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
NF-kB is activated and signals survivalR-HSA-2095609.28
ZBP1(DAI) mediated induction of type I IFNsR-HSA-16063228.28
Activation of NF-kappaB in B cellsR-HSA-11690916.94
TCR signalingR-HSA-2024036.64
Interleukin-1 signalingR-HSA-4466527.52
TRAF6 mediated NF-kB activationR-HSA-9335428.4
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10R-HSA-9335439.4
Toll Like Receptor TLR6:TLR2 CascadeR-HSA-1681886.56
Downstream TCR signalingR-HSA-2024247.01
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Toll Like Receptor 4 (TLR4) CascadeR-HSA-1660166.11
Toll Like Receptor 7/8 (TLR7/8) CascadeR-HSA-1681816.68
NOD1/2 Signaling PathwayR-HSA-1686387.85
p75NTR signals via NF-kBR-HSA-1936398.98
TAK1 activates NFkB by phosphorylation and activation of IKKs complexR-HSA-4459898.08
RIP-mediated NFkB activation via ZBP1R-HSA-18104768.59
Cytosolic sensors of pathogen-associated DNA R-HSA-18349496.94
Diseases of Immune SystemR-HSA-52602718.34
Toll Like Receptor 10 (TLR10) CascadeR-HSA-1681426.73
MyD88-independent TLR3/TLR4 cascade R-HSA-1661666.47
Toll Like Receptor TLR1:TLR2 CascadeR-HSA-1681796.51
IKBKB deficiency causes SCIDR-HSA-560263611.4
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationR-HSA-9751386.72
Toll Like Receptor 5 (TLR5) CascadeR-HSA-1681766.73
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysR-HSA-1686437.31
MyD88:Mal cascade initiated on plasma membraneR-HSA-1660586.56
CLEC7A (Dectin-1) signalingR-HSA-56077646.38
Activated TLR4 signallingR-HSA-1660546.27
FCERI mediated NF-kB activationR-HSA-28718375.11
Signal TransductionR-HSA-1625821.78
Toll Like Receptor 9 (TLR9) CascadeR-HSA-1681386.62
Associated GO terms for Molecular function
purine ribonucleoside triphosphate bindingGO:00356392.22
enzyme bindingGO:00198992.27
signal transducer activityGO:00048712.28
heterocyclic compound bindingGO:19013631.06
purine nucleoside bindingGO:00018832.22
nucleoside bindingGO:00018822.21
nucleotide bindingGO:00001661.96
protein serine/threonine kinase activityGO:00046743.64
transferase activityGO:00167401.95
nucleoside phosphate bindingGO:19012651.96
ribonucleoside bindingGO:00325492.22
IkappaB kinase activityGO:00083848.64
protein kinase activityGO:00046723.27
identical protein bindingGO:00428022.63
protein homodimerization activityGO:00428033.16
kinase activityGO:00163012.93
small molecule bindingGO:00360941.89
kinase bindingGO:00199003.32
purine nucleotide bindingGO:00170762.19
protein kinase bindingGO:00199013.44
adenyl ribonucleotide bindingGO:00325592.41
adenyl nucleotide bindingGO:00305542.4
carbohydrate derivative bindingGO:00973672.03
organic cyclic compound bindingGO:00971591.05
catalytic activityGO:00038241.05
phosphotransferase activity, alcohol group as acceptorGO:00167733.08
scaffold protein bindingGO:00971105.93
ATP bindingGO:00055242.43
protein bindingGO:00055150.46
transferase activity, transferring phosphorus-containing groupsGO:00167722.77
purine ribonucleotide bindingGO:00325552.2
protein dimerization activityGO:00469832.72
protein heterodimerization activityGO:00469823.64
purine ribonucleoside bindingGO:00325502.22
ribonucleotide bindingGO:00325532.19