Gene table of IRAK3 : interleukin 1 receptor associated kinase 3

Gene-disease associations table

Disease ID	Disease name	Source of annotation with IRAK3	OMIM link	Number of associated genes	genes
611064	ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 5	ClinVar, OMIM	link to OMIM	1	IRAK3
PS142623	HIRSCHSPRUNG DISEASE	ClinVar	link to OMIM	21	TSC2, KDR, GDNF, PTCH1, GFRA1, NTF3, IRAK3, EDN3, ZHX2, THBS4, AHNAK, POLR2F, FBN1, RET, CNTN5, DPYD, EDNRB, CREBBP, SEMA3D, FAT3, PLAU

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Apoptosis	hsa04210	6.23
Neurotrophin signaling pathway	hsa04722	5.78

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.56
Signaling by Interleukins	R-HSA-449147	4.71
Immune System	R-HSA-168256	2.37
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.51
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.11
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.51
Toll-Like Receptors Cascades	R-HSA-168898	5.91
Innate Immune System	R-HSA-168249	3.17
MyD88:Mal cascade initiated on plasma membrane	R-HSA-166058	6.56
Activated TLR4 signalling	R-HSA-166054	6.27
Interleukin-1 signaling	R-HSA-446652	7.52

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
binding	GO:0005488	0.18
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
magnesium ion binding	GO:0000287	4.41
ion binding	GO:0043167	1.36
protein serine/threonine kinase activity	GO:0004674	3.64
transferase activity	GO:0016740	1.95
nucleoside phosphate binding	GO:1901265	1.96
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
protein kinase activity	GO:0004672	3.27
metal ion binding	GO:0046872	1.41
ATP binding	GO:0005524	2.43
protein homodimerization activity	GO:0042803	3.16
kinase activity	GO:0016301	2.93
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
adenyl ribonucleotide binding	GO:0032559	2.41
identical protein binding	GO:0042802	2.63
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
protein dimerization activity	GO:0046983	2.72
protein heterodimerization activity	GO:0046982	3.64
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19