| Disease ID | Disease name | Source of annotation with IRAK4 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 607676 | IRAK4 DEFICIENCY | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | IRAK4 |
| PS610799 | INVASIVE PNEUMOCOCCAL DISEASE, RECURRENT ISOLATED | ClinVar, OMIM | link to OMIM | 3 | IKBKG, TIRAP, IRAK4 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Pertussis | hsa05133 | 6.46 |
| Tuberculosis | hsa05152 | 5.17 |
| Toll-like receptor signaling pathway | hsa04620 | 6.0 |
| Chagas disease (American trypanosomiasis) | hsa05142 | 5.99 |
| Leishmaniasis | hsa05140 | 6.32 |
| Neurotrophin signaling pathway | hsa04722 | 5.78 |
| Toxoplasmosis | hsa05145 | 5.71 |
| Influenza A | hsa05164 | 5.21 |
| Apoptosis | hsa04210 | 6.23 |
| NF-kappa B signaling pathway | hsa04064 | 6.21 |
| Measles | hsa05162 | 5.6 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| MyD88 deficiency (TLR5) | R-HSA-5602680 | 11.4 |
| Signaling by Interleukins | R-HSA-449147 | 4.71 |
| Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 6.51 |
| Immune System | R-HSA-168256 | 2.37 |
| Toll Like Receptor 5 (TLR5) Cascade | R-HSA-168176 | 6.73 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 3.74 |
| Diseases associated with the TLR signaling cascade | R-HSA-5602358 | 8.34 |
| IRAK4 deficiency (TLR2/4) | R-HSA-5603041 | 9.52 |
| Disease | R-HSA-1643685 | 3.33 |
| Toll Like Receptor 10 (TLR10) Cascade | R-HSA-168142 | 6.73 |
| Toll-Like Receptors Cascades | R-HSA-168898 | 5.91 |
| Interleukin-1 signaling | R-HSA-446652 | 7.52 |
| Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 6.56 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 6.11 |
| Toll Like Receptor 7/8 (TLR7/8) Cascade | R-HSA-168181 | 6.68 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Diseases of Immune System | R-HSA-5260271 | 8.34 |
| IRAK4 deficiency (TLR5) | R-HSA-5603037 | 10.98 |
| Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 6.51 |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | R-HSA-975138 | 6.72 |
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | R-HSA-975110 | 9.08 |
| MyD88 cascade initiated on plasma membrane | R-HSA-975871 | 6.73 |
| MyD88 dependent cascade initiated on endosome | R-HSA-975155 | 6.68 |
| MyD88:Mal cascade initiated on plasma membrane | R-HSA-166058 | 6.56 |
| MyD88 deficiency (TLR2/4) | R-HSA-5602498 | 9.52 |
| Activated TLR4 signalling | R-HSA-166054 | 6.27 |
| Toll Like Receptor 9 (TLR9) Cascade | R-HSA-168138 | 6.62 |
| GO term | GO ID | GO IC |
|---|---|---|
| cytokine receptor binding | GO:0005126 | 4.14 |
| interleukin-1 receptor binding | GO:0005149 | 6.85 |
| purine ribonucleoside triphosphate binding | GO:0035639 | 2.22 |
| binding | GO:0005488 | 0.18 |
| ion binding | GO:0043167 | 1.36 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| nucleoside phosphate binding | GO:1901265 | 1.96 |
| nucleoside binding | GO:0001882 | 2.21 |
| cation binding | GO:0043169 | 1.4 |
| magnesium ion binding | GO:0000287 | 4.41 |
| ribonucleoside binding | GO:0032549 | 2.22 |
| nucleotide binding | GO:0000166 | 1.96 |
| protein serine/threonine kinase activity | GO:0004674 | 3.64 |
| transferase activity | GO:0016740 | 1.95 |
| purine nucleoside binding | GO:0001883 | 2.22 |
| protein kinase activity | GO:0004672 | 3.27 |
| purine nucleotide binding | GO:0017076 | 2.19 |
| metal ion binding | GO:0046872 | 1.41 |
| ATP binding | GO:0005524 | 2.43 |
| kinase activity | GO:0016301 | 2.93 |
| small molecule binding | GO:0036094 | 1.89 |
| catalytic activity | GO:0003824 | 1.05 |
| growth factor receptor binding | GO:0070851 | 4.87 |
| phosphotransferase activity, alcohol group as acceptor | GO:0016773 | 3.08 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| adenyl nucleotide binding | GO:0030554 | 2.4 |
| carbohydrate derivative binding | GO:0097367 | 2.03 |
| adenyl ribonucleotide binding | GO:0032559 | 2.41 |
| protein binding | GO:0005515 | 0.46 |
| transferase activity, transferring phosphorus-containing groups | GO:0016772 | 2.77 |
| purine ribonucleotide binding | GO:0032555 | 2.2 |
| receptor binding | GO:0005102 | 2.43 |
| purine ribonucleoside binding | GO:0032550 | 2.22 |
| ribonucleotide binding | GO:0032553 | 2.19 |