Gene table of ITGA2 : integrin subunit alpha 2

Gene-disease associations table

Disease IDDisease nameSource of annotation with ITGA2OMIM linkNumber of associated genesgenes
PS231200BLEEDING DISORDER, PLATELET-TYPEOMIM link to OMIM 21NBEAL2, ANO6, GP1BA, ITGA2, GFI1B, ITGA2B, PLAU, PRKACG, P2RY12, ACTN1, TBXAS1, P2RX1, GP6, CD36, SLFN14, ITGB3, GP9, GP1BB, RASGRP2, TBXA2R, MYH9

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Annotation of the gene ITGA2

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Platelet activationhsa046115.66
Focal adhesionhsa045104.92
Proteoglycans in cancerhsa052055.02
Pathways in cancerhsa052003.98
ECM-receptor interactionhsa045126.09
Small cell lung cancerhsa052226.17
Hematopoietic cell lineagehsa046406.18
Hypertrophic cardiomyopathy (HCM)hsa054106.21
Phagosomehsa041455.27
Arrhythmogenic right ventricular cardiomyopathy (ARVC)hsa054126.32
Regulation of actin cytoskeletonhsa048104.9
Dilated cardiomyopathyhsa054146.08
PI3K-Akt signaling pathwayhsa041514.21
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Integrin cell surface interactionsR-HSA-2160836.57
L1CAM interactionsR-HSA-3737606.19
Laminin interactionsR-HSA-30001578.08
ECM proteoglycansR-HSA-30001786.75
Platelet Adhesion to exposed collagenR-HSA-758929.08
Extracellular matrix organizationR-HSA-14742444.91
CHL1 interactionsR-HSA-4470419.81
Syndecan interactionsR-HSA-30001708.23
Non-integrin membrane-ECM interactionsR-HSA-30001717.1
Axon guidanceR-HSA-4224753.93
HemostasisR-HSA-1095823.98
Developmental BiologyR-HSA-12667383.48
Associated GO terms for Molecular function
GO termGO IDGO IC
protein binding involved in cell-matrix adhesionGO:00986347.95
signaling receptor activityGO:00380232.49
protein binding involved in cell adhesionGO:00986316.91
extracellular matrix bindingGO:00508405.79
collagen binding involved in cell-matrix adhesionGO:00986398.13
collagen receptor activityGO:00380648.35
molecular transducer activityGO:00600892.32
macromolecular complex bindingGO:00448772.61
bindingGO:00054880.18
signal transducer activityGO:00048712.28
cation bindingGO:00431691.4
ion bindingGO:00431671.36
protein complex bindingGO:00324033.09
metal ion bindingGO:00468721.41
integrin bindingGO:00051785.07
cell adhesion molecule bindingGO:00508394.5
protein dimerization activityGO:00469832.72
laminin bindingGO:00432366.34
protein heterodimerization activityGO:00469823.64
virus receptor activityGO:00016185.49
transmembrane signaling receptor activityGO:00048882.57
protein bindingGO:00055150.46
receptor bindingGO:00051022.43
collagen bindingGO:00055185.58
transmembrane receptor activityGO:00996002.53
receptor activityGO:00048722.32