Gene table of ITK : IL2 inducible T-cell kinase

Gene-disease associations table

Disease ID	Disease name	Source of annotation with ITK	OMIM link	Number of associated genes	genes
PS308240	LYMPHOPROLIFERATIVE SYNDROME	ClinVar, OMIM, HUMSAVAR	link to OMIM	4	ITK, SH2D1A, CD27, XIAP

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
T cell receptor signaling pathway	hsa04660	6.01
Leukocyte transendothelial migration	hsa04670	5.74
Chemokine signaling pathway	hsa04062	5.19

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Generation of second messenger molecules	R-HSA-202433	7.34
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03
Innate Immune System	R-HSA-168249	3.17
Immune System	R-HSA-168256	2.37
TCR signaling	R-HSA-202403	6.64
FCERI mediated Ca+2 mobilization	R-HSA-2871809	5.45
Adaptive Immune System	R-HSA-1280218	3.19

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
binding	GO:0005488	0.18
purine nucleoside binding	GO:0001883	2.22
ion binding	GO:0043167	1.36
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
ribonucleoside binding	GO:0032549	2.22
nucleotide binding	GO:0000166	1.96
transferase activity	GO:0016740	1.95
non-membrane spanning protein tyrosine kinase activity	GO:0004715	5.91
protein tyrosine kinase activity	GO:0004713	4.54
protein kinase activity	GO:0004672	3.27
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
ATP binding	GO:0005524	2.43
kinase activity	GO:0016301	2.93
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
adenyl nucleotide binding	GO:0030554	2.4
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
organic cyclic compound binding	GO:0097159	1.05
carbohydrate derivative binding	GO:0097367	2.03
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
receptor binding	GO:0005102	2.43
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19