Gene table of KALRN : kalirin, RhoGEF kinase

Gene-disease associations table

Disease ID	Disease name	Source of annotation with KALRN	OMIM link	Number of associated genes	genes
608901	CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 5	ClinVar, OMIM	link to OMIM	1	KALRN

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Annotation of the gene KALRN

Associated genes in ENSEMBL

ENSG00000160145

Associated proteins - SwissProt Accession ID

O60229

Associated PDB IDs

Cytogenetic Band

3q21.1

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	7.05
MAPK family signaling cascades	R-HSA-5683057	4.89
Signalling by NGF	R-HSA-166520	4.23
G alpha (12/13) signalling events	R-HSA-416482	6.75
GPCR downstream signaling	R-HSA-388396	3.07
MAPK6/MAPK4 signaling	R-HSA-5687128	6.54
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26
Signaling by Rho GTPases	R-HSA-194315	4.43
G alpha (q) signalling events	R-HSA-416476	5.42
EPHB-mediated forward signaling	R-HSA-3928662	7.62
Rho GTPase cycle	R-HSA-194840	6.04
Signal Transduction	R-HSA-162582	1.78
p75 NTR receptor-mediated signalling	R-HSA-193704	6.59
Signaling by GPCR	R-HSA-372790	2.68
Axon guidance	R-HSA-422475	3.93
EPH-Ephrin signaling	R-HSA-2682334	6.43
Developmental Biology	R-HSA-1266738	3.48
NRAGE signals death through JNK	R-HSA-193648	7.49

Associated GO terms for Molecular function

GO term	GO ID	GO IC
Rho guanyl-nucleotide exchange factor activity	GO:0005089	5.37
Ras guanyl-nucleotide exchange factor activity	GO:0005088	4.31
purine ribonucleoside triphosphate binding	GO:0035639	2.22
guanyl-nucleotide exchange factor activity	GO:0005085	4.02
enzyme activator activity	GO:0008047	3.56
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
molecular function regulator	GO:0098772	2.51
ribonucleoside binding	GO:0032549	2.22
ion binding	GO:0043167	1.36
protein serine/threonine kinase activity	GO:0004674	3.64
transferase activity	GO:0016740	1.95
nucleoside phosphate binding	GO:1901265	1.96
protein kinase activity	GO:0004672	3.27
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
ATP binding	GO:0005524	2.43
enzyme regulator activity	GO:0030234	2.85
kinase activity	GO:0016301	2.93
GTPase activator activity	GO:0005096	4.11
small molecule binding	GO:0036094	1.89
GTPase regulator activity	GO:0030695	4.01
nucleoside-triphosphatase regulator activity	GO:0060589	3.92
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
catalytic activity	GO:0003824	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
binding	GO:0005488	0.18