Gene table of KDM1A : lysine demethylase 1A

Gene-disease associations table

Disease ID	Disease name	Source of annotation with KDM1A	OMIM link	Number of associated genes	genes
616728	CLEFT PALATE, PSYCHOMOTOR RETARDATION, AND DISTINCTIVE FACIAL FEATURES	ClinVar, OMIM	link to OMIM	1	KDM1A

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Annotation of the gene KDM1A

Associated genes in ENSEMBL

ENSG00000004487

Associated proteins - SwissProt Accession ID

O60341

Associated PDB IDs

Cytogenetic Band

1p36.12

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
RHO GTPase Effectors	R-HSA-195258	4.94
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	R-HSA-5625886	7.94
RHO GTPases activate PKNs	R-HSA-5625740	7.1
Signaling by Rho GTPases	R-HSA-194315	4.43
Chromatin organization	R-HSA-4839726	5.19
HDMs demethylate histones	R-HSA-3214842	8.4
HDACs deacetylate histones	R-HSA-3214815	7.08
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	5.88
Hemostasis	R-HSA-109582	3.98
Signal Transduction	R-HSA-162582	1.78
Chromatin modifying enzymes	R-HSA-3247509	5.19

Associated GO terms for Molecular function

GO term	GO ID	GO IC
telomeric repeat-containing RNA binding	GO:0061752	9.05
androgen receptor binding	GO:0050681	6.07
enzyme binding	GO:0019899	2.27
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
bHLH transcription factor binding	GO:0043425	6.41
MRF binding	GO:0043426	8.13
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
oxidoreductase activity	GO:0016491	3.12
coenzyme binding	GO:0050662	4.53
flavin adenine dinucleotide binding	GO:0050660	5.41
histone deacetylase activity	GO:0004407	6.0
transcription coactivator activity	GO:0003713	4.04
transcription cofactor activity	GO:0003712	3.44
nucleotide binding	GO:0000166	1.96
transcription factor activity, transcription factor binding	GO:0000989	3.36
transcription factor activity, protein binding	GO:0000988	3.35
histone demethylase activity (H3-dimethyl-K4 specific)	GO:0034648	8.64
hydrolase activity	GO:0016787	1.9
deacetylase activity	GO:0019213	5.7
steroid hormone receptor binding	GO:0035258	5.32
sequence-specific DNA binding	GO:0043565	2.79
telomeric DNA binding	GO:0042162	6.34
transcription factor binding	GO:0008134	3.46
nuclear hormone receptor binding	GO:0035257	4.7
ligand-dependent nuclear receptor transcription coactivator activity	GO:0030374	5.77
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
cofactor binding	GO:0048037	4.16
hormone receptor binding	GO:0051427	4.57
receptor binding	GO:0005102	2.43
RNA polymerase II transcription factor binding	GO:0001085	5.08
transcription regulatory region DNA binding	GO:0044212	3.03
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
organic cyclic compound binding	GO:0097159	1.05
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	GO:0016810	4.76
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	GO:0016811	5.28
regulatory region nucleic acid binding	GO:0001067	3.03
demethylase activity	GO:0032451	6.21
histone demethylase activity	GO:0032452	6.48
histone demethylase activity (H3-K4 specific)	GO:0032453	7.95
histone demethylase activity (H3-K9 specific)	GO:0032454	7.66
RNA binding	GO:0003723	2.36
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
protein deacetylase activity	GO:0033558	5.95
chromatin binding	GO:0003682	3.64
p53 binding	GO:0002039	5.53
nucleic acid binding transcription factor activity	GO:0001071	2.65