Gene table of KL : klotho

Gene-disease associations table

Disease IDDisease nameSource of annotation with KLOMIM linkNumber of associated genesgenes
211900TUMORAL CALCINOSIS, HYPERPHOSPHATEMIC, FAMILIALOMIM, HUMSAVAR link to OMIM 3FGF23, KL, GALNT3

Download the gene annotation in CSV format

Annotation of the gene KL

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Metabolic pathwayshsa011002.49
Endocrine and other factor-regulated calcium reabsorptionhsa049617.12
Pentose and glucuronate interconversionshsa000407.68
Starch and sucrose metabolismhsa005006.91
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Interleukin-2 signalingR-HSA-4519275.05
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
GAB1 signalosomeR-HSA-1802926.31
Developmental BiologyR-HSA-12667383.48
Signaling by VEGFR-HSA-1941384.66
FCERI mediated MAPK activationR-HSA-28717964.32
IRS-mediated signallingR-HSA-1123994.87
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
Signaling by EGFRR-HSA-1779294.59
PI-3K cascade:FGFR3R-HSA-56547106.37
DAP12 interactionsR-HSA-21721274.56
Downstream signaling of activated FGFR4R-HSA-56547164.71
Signaling by ERBB2R-HSA-12279864.66
VEGFR2 mediated cell proliferationR-HSA-52189215.07
PI3K/AKT activationR-HSA-1982036.32
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Frs2-mediated activationR-HSA-1709685.12
PI3K events in ERBB2 signalingR-HSA-19636426.37
Downstream signal transductionR-HSA-1867634.65
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.95
Signalling to p38 via RIT and RINR-HSA-1877065.12
FRS-mediated FGFR2 signalingR-HSA-56547005.14
FRS-mediated FGFR4 signalingR-HSA-56547125.14
FRS-mediated FGFR3 signalingR-HSA-56547065.14
Downstream signaling of activated FGFR3R-HSA-56547084.71
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Interleukin receptor SHC signalingR-HSA-9125265.09
Innate Immune SystemR-HSA-1682493.17
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
Prolonged ERK activation eventsR-HSA-1698935.11
Signaling by FGFR2R-HSA-56547384.68
GRB2 events in EGFR signalingR-HSA-1798125.15
Signaling by FGFR1R-HSA-56547364.69
PI3K events in ERBB4 signalingR-HSA-12503426.37
PI3K CascadeR-HSA-1097046.68
Axon guidanceR-HSA-4224753.93
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
FGFR1 ligand binding and activationR-HSA-1902428.98
Signaling by LeptinR-HSA-25865525.1
Constitutive Signaling by Aberrant PI3K in CancerR-HSA-22195307.05
IGF1R signaling cascadeR-HSA-24289244.85
IRS-related events triggered by IGF1RR-HSA-24289284.85
Signaling by Insulin receptorR-HSA-747524.73
DiseaseR-HSA-16436853.33
Insulin receptor signalling cascadeR-HSA-747514.85
FGFR1c and Klotho ligand binding and activationR-HSA-19037411.4
Downstream signaling of activated FGFR1R-HSA-56546874.71
PI-3K cascade:FGFR4R-HSA-56547206.37
PI-3K cascade:FGFR1R-HSA-56546896.37
SHC-mediated cascade:FGFR1R-HSA-56546888.59
Negative regulation of FGFR1 signalingR-HSA-56547267.98
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
PI3K/AKT Signaling in CancerR-HSA-22195286.56
Diseases of signal transductionR-HSA-56632024.89
Immune SystemR-HSA-1682562.37
Signalling to RASR-HSA-1670445.08
PI-3K cascade:FGFR2R-HSA-56546956.37
Downstream signaling of activated FGFR2R-HSA-56546964.71
SHC1 events in EGFR signalingR-HSA-1803365.15
FRS-mediated FGFR1 signalingR-HSA-56546935.14
SHC1 events in ERBB2 signalingR-HSA-12501965.15
ARMS-mediated activationR-HSA-1709845.12
SHC1 events in ERBB4 signalingR-HSA-12503475.15
Signaling by PDGFR-HSA-1867974.53
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Signaling by InterleukinsR-HSA-4491474.71
Cytokine Signaling in Immune systemR-HSA-12802153.74
SOS-mediated signallingR-HSA-1124125.15
Signaling by ERBB4R-HSA-12363944.7
MAPK1/MAPK3 signalingR-HSA-56849965.11
Adaptive Immune SystemR-HSA-12802183.19
MAPK family signaling cascadesR-HSA-56830574.89
PIP3 activates AKT signalingR-HSA-12576046.37
Phospholipase C-mediated cascade: FGFR1R-HSA-56542197.43
RAF/MAP kinase cascadeR-HSA-56730015.15
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
Signaling by FGFRR-HSA-1902364.67
Signaling by SCF-KITR-HSA-14335574.73
NCAM signaling for neurite out-growthR-HSA-3751654.9
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
Signalling by NGFR-HSA-1665204.23
Signaling by GPCRR-HSA-3727902.68
Signalling to ERKsR-HSA-1876875.04
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
Ras guanyl-nucleotide exchange factor activityGO:00050884.31
phosphatidylinositol 3-kinase activityGO:00350045.49
hydrolase activityGO:00167871.9
guanyl-nucleotide exchange factor activityGO:00050854.02
hydrolase activity, acting on glycosyl bondsGO:00167984.91
bindingGO:00054880.18
signal transducer activityGO:00048712.28
molecular function regulatorGO:00987722.51
phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469345.61
growth factor bindingGO:00198384.89
beta-glucosidase activityGO:00084227.95
phosphatidylinositol bisphosphate kinase activityGO:00528135.56
transferase activityGO:00167401.95
beta-glucuronidase activityGO:00045668.64
hormone activityGO:00051794.95
glucosidase activityGO:00159267.1
1-phosphatidylinositol-3-kinase activityGO:00163035.98
kinase activityGO:00163012.93
lipid bindingGO:00082893.26
fibroblast growth factor bindingGO:00171346.52
small molecule bindingGO:00360941.89
catalytic activityGO:00038241.05
vitamin D bindingGO:00054997.95
steroid bindingGO:00054965.24
growth factor receptor bindingGO:00708514.87
phosphatidylinositol kinase activityGO:00527425.81
organic cyclic compound bindingGO:00971591.05
vitamin bindingGO:00198425.34
phosphotransferase activity, alcohol group as acceptorGO:00167733.08
transferase activity, transferring phosphorus-containing groupsGO:00167722.77
protein bindingGO:00055150.46
hydrolase activity, hydrolyzing O-glycosyl compoundsGO:00045535.14
receptor bindingGO:00051022.43
fibroblast growth factor receptor bindingGO:00051046.41