Gene table of KLKB1 : kallikrein B1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with KLKB1	OMIM link	Number of associated genes	genes
612423	PREKALLIKREIN DEFICIENCY	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	KLKB1

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Complement and coagulation cascades	hsa04610	6.58

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Degradation of the extracellular matrix	R-HSA-1474228	6.11
Activation of Matrix Metalloproteinases	R-HSA-1592389	8.03
Extracellular matrix organization	R-HSA-1474244	4.91
Intrinsic Pathway of Fibrin Clot Formation	R-HSA-140837	8.52
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	7.7
Hemostasis	R-HSA-109582	3.98

Associated GO terms for Molecular function

GO term	GO ID	GO IC
serine-type endopeptidase activity	GO:0004252	4.4
monooxygenase activity	GO:0004497	5.1
endopeptidase activity	GO:0004175	3.63
serine-type peptidase activity	GO:0008236	4.27
binding	GO:0005488	0.18
peptidase activity	GO:0008233	3.23
heterocyclic compound binding	GO:1901363	1.06
oxidoreductase activity	GO:0016491	3.12
cation binding	GO:0043169	1.4
transition metal ion binding	GO:0046914	2.48
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	4.65
ion binding	GO:0043167	1.36
iron ion binding	GO:0005506	4.65
metal ion binding	GO:0046872	1.41
hydrolase activity	GO:0016787	1.9
heme binding	GO:0020037	4.86
serine hydrolase activity	GO:0017171	4.26
catalytic activity	GO:0003824	1.05
tetrapyrrole binding	GO:0046906	4.8
organic cyclic compound binding	GO:0097159	1.05
peptidase activity, acting on L-amino acid peptides	GO:0070011	3.26
protein binding	GO:0005515	0.46