Gene table of LRP5 : LDL receptor related protein 5

Gene-disease associations table

Disease IDDisease nameSource of annotation with LRP5OMIM linkNumber of associated genesgenes
173900POLYCYSTIC KIDNEY DISEASE 1ClinVar link to OMIM 2PKD1, LRP5
PS174050POLYCYSTIC LIVER DISEASEClinVar link to OMIM 3SEC63, PRKCSH, LRP5
144750ENDOSTEAL HYPEROSTOSIS, AUTOSOMAL DOMINANTOMIM, HUMSAVAR link to OMIM 1LRP5
601884BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 1ClinVar, OMIM, HUMSAVAR link to OMIM 1LRP5
259770OSTEOPOROSIS-PSEUDOGLIOMA SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 1LRP5
607636VAN BUCHEM DISEASE, TYPE 2ClinVar, OMIM, HUMSAVAR link to OMIM 1LRP5
PS133780EXUDATIVE VITREORETINOPATHYOMIM, HUMSAVAR link to OMIM 6NDP, TSPAN12, ZNF408, PRSS23, FZD4, LRP5
166710OSTEOPOROSISClinVar, OMIM link to OMIM 7WNT1, CALCR, PDLIM4, COL1A1, COL1A2, VDR, LRP5
PS607634OSTEOPETROSIS, AUTOSOMAL DOMINANTClinVar, OMIM, HUMSAVAR link to OMIM 2LRP5, CLCN7

Download the gene annotation in CSV format

Annotation of the gene LRP5

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Wnt signaling pathwayhsa043105.49
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Signaling by WntR-HSA-1957214.79
misspliced LRP5 mutants have enhanced beta-catenin-dependent signalingR-HSA-533971710.4
RNF mutants show enhanced WNT signaling and proliferationR-HSA-53405889.98
Diseases of signal transductionR-HSA-56632024.89
Signaling by WNT in cancerR-HSA-47912757.89
disassembly of the destruction complex and recruitment of AXIN to the membraneR-HSA-46412628.03
Signal TransductionR-HSA-1625821.78
TCF dependent signaling in response to WNTR-HSA-2016815.36
regulation of FZD by ubiquitinationR-HSA-46412638.59
negative regulation of TCF-dependent signaling by WNT ligand antagonistsR-HSA-37724709.08
DiseaseR-HSA-16436853.33
Associated GO terms for Molecular function
GO termGO IDGO IC
toxin transporter activityGO:00195347.95
coreceptor activity involved in Wnt signaling pathwayGO:00719367.66
protein bindingGO:00055150.46
coreceptor activity involved in canonical Wnt signaling pathwayGO:19049289.05
transporter activityGO:00052152.57
Wnt-activated receptor activityGO:00428136.65
molecular transducer activityGO:00600892.32
transmembrane signaling receptor activityGO:00048882.57
bindingGO:00054880.18
signal transducer activityGO:00048712.28
Wnt-protein bindingGO:00171476.3
signaling receptor activityGO:00380232.49
coreceptor activityGO:00150266.1
transmembrane receptor activityGO:00996002.53
receptor activityGO:00048722.32