Gene table of LRRK2 : leucine rich repeat kinase 2

Gene-disease associations table

Disease IDDisease nameSource of annotation with LRRK2OMIM linkNumber of associated genesgenes
PS168600PARKINSON DISEASEClinVar, OMIM, HUMSAVAR link to OMIM 30ATP13A2, FGF20, VPS13C, DNAJC13, ATXN2, PINK1, CHCHD2, ADH1C, UCHL1, GIGYF2, SYNJ1, PODXL, HTRA2, LRRK2, TBP, PARK2, ATXN8OS, SNCAIP, GBA, SNCA, NR4A2, PLA2G6, GLUD2, PARK7, ATXN3, MAPT, DNAJC6, EIF4G1, FBXO7, VPS35

Download the gene annotation in CSV format

Annotation of the gene LRRK2

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST
Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Parkinson's diseasehsa050125.59
Associated REACTOME pathways
Associated GO terms for Molecular function
GO termGO IDGO IC
bindingGO:00054880.18
receptor signaling complex scaffold activityGO:00301596.6
beta-catenin destruction complex bindingGO:19047139.05
purine ribonucleoside triphosphate bindingGO:00356392.22
heterocyclic compound bindingGO:19013631.06
Rho GTPase bindingGO:00170485.36
small GTPase bindingGO:00312674.13
GTPase bindingGO:00510204.05
enzyme inhibitor activityGO:00048573.78
macromolecular complex bindingGO:00448772.61
protein complex scaffoldGO:00329475.5
signal transducer activityGO:00048712.28
ion channel bindingGO:00443255.02
co-receptor bindingGO:00397067.54
guanyl ribonucleotide bindingGO:00325613.73
nucleoside phosphate bindingGO:19012651.96
nucleoside bindingGO:00018822.21
glycoprotein bindingGO:00019485.11
molecular function regulatorGO:00987722.51
pyrophosphatase activityGO:00164623.04
SNARE bindingGO:00001494.87
phosphotransferase activity, alcohol group as acceptorGO:00167733.08
nucleotide bindingGO:00001661.96
actin bindingGO:00037793.74
protein serine/threonine kinase activityGO:00046743.64
transferase activityGO:00167401.95
protein serine/threonine/tyrosine kinase activityGO:00047126.07
purine nucleoside bindingGO:00018832.22
protein kinase activityGO:00046723.27
protein complex bindingGO:00324033.09
purine nucleotide bindingGO:00170762.19
syntaxin-1 bindingGO:00170756.85
enzyme regulator activityGO:00302342.85
ATP bindingGO:00055242.43
GTP bindingGO:00055253.78
hydrolase activityGO:00167871.9
tubulin bindingGO:00156314.1
protein kinase A bindingGO:00510186.02
structural molecule activityGO:00051983.1
GTPase activator activityGO:00050964.11
microtubule bindingGO:00080174.42
ribonucleoside bindingGO:00325492.22
GTPase activityGO:00039244.31
nucleoside-triphosphatase activityGO:00171113.09
Ras GTPase bindingGO:00170164.2
small molecule bindingGO:00360941.89
catalytic activityGO:00038241.05
clathrin bindingGO:00302765.55
enzyme bindingGO:00198992.27
peroxidase inhibitor activityGO:00364799.74
nucleoside-triphosphatase regulator activityGO:00605893.92
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydridesGO:00168183.03
protein bindingGO:00055150.46
adenyl nucleotide bindingGO:00305542.4
carbohydrate derivative bindingGO:00973672.03
organic cyclic compound bindingGO:00971591.05
cytoskeletal protein bindingGO:00080923.02
kinase activityGO:00163012.93
hydrolase activity, acting on acid anhydridesGO:00168173.03
purine ribonucleoside bindingGO:00325502.22
guanyl nucleotide bindingGO:00190013.73
adenyl ribonucleotide bindingGO:00325592.41
identical protein bindingGO:00428022.63
GTPase regulator activityGO:00306954.01
transferase activity, transferring phosphorus-containing groupsGO:00167722.77
purine ribonucleotide bindingGO:00325552.2
syntaxin bindingGO:00199055.19
protein dimerization activityGO:00469832.72
protein homodimerization activityGO:00428033.16
GTP-dependent protein kinase activityGO:00342119.74
MAP kinase kinase activityGO:00047087.25
ribonucleotide bindingGO:00325532.19
enzyme activator activityGO:00080473.56