Gene table of MAP3K1 : mitogen-activated protein kinase kinase kinase 1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with MAP3K1	OMIM link	Number of associated genes	genes
PS400044	46,XY SEX REVERSAL	ClinVar, OMIM, HUMSAVAR	link to OMIM	9	AKR1C2, AKR1C4, NR0B1, SRY, MAP3K1, CBX2, NR5A1, DHH, ZFPM2

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Annotation of the gene MAP3K1

Associated genes in ENSEMBL

ENSG00000095015

Associated proteins - SwissProt Accession ID

Q13233

Associated PDB IDs

Cytogenetic Band

5q11.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
MAPK signaling pathway	hsa04010	4.63
RIG-I-like receptor signaling pathway	hsa04622	6.62
GnRH signaling pathway	hsa04912	6.18
Neurotrophin signaling pathway	hsa04722	5.78
Ubiquitin mediated proteolysis	hsa04120	5.63
HTLV-I infection	hsa05166	4.59
Hepatitis B	hsa05161	5.52

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
TRAF6 mediated NF-kB activation	R-HSA-933542	8.4
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.51
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.51
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.73
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.72
FCERI mediated MAPK activation	R-HSA-2871796	4.32
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.11
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.73
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.73
Toll-Like Receptors Cascades	R-HSA-168898	5.91
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.68
Immune System	R-HSA-168256	2.37
Innate Immune System	R-HSA-168249	3.17
MyD88:Mal cascade initiated on plasma membrane	R-HSA-166058	6.56
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.56
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	R-HSA-168928	6.7
Activated TLR4 signalling	R-HSA-166054	6.27
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	6.68
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	6.62

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
enzyme binding	GO:0019899	2.27
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
transition metal ion binding	GO:0046914	2.48
receptor signaling protein activity	GO:0005057	4.76
ribonucleoside binding	GO:0032549	2.22
ion binding	GO:0043167	1.36
protein serine/threonine kinase activity	GO:0004674	3.64
transferase activity	GO:0016740	1.95
purine nucleoside binding	GO:0001883	2.22
protein kinase activity	GO:0004672	3.27
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
ATP binding	GO:0005524	2.43
kinase activity	GO:0016301	2.93
protein kinase binding	GO:0019901	3.44
kinase binding	GO:0019900	3.32
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
organic cyclic compound binding	GO:0097159	1.05
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
receptor signaling protein serine/threonine kinase activity	GO:0004702	5.23
purine ribonucleotide binding	GO:0032555	2.2
MAP kinase kinase kinase activity	GO:0004709	6.6
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
zinc ion binding	GO:0008270	2.66