| Disease ID | Disease name | Source of annotation with MCM8 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 612885 | PREMATURE OVARIAN FAILURE 10 | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | MCM8 |
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| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Activation of the pre-replicative complex | R-HSA-68962 | 8.08 |
| Cell Cycle, Mitotic | R-HSA-69278 | 4.16 |
| Cell Cycle | R-HSA-1640170 | 3.89 |
| Switching of origins to a post-replicative state | R-HSA-69052 | 6.85 |
| Cell Cycle Checkpoints | R-HSA-69620 | 5.64 |
| DNA strand elongation | R-HSA-69190 | 7.94 |
| Orc1 removal from chromatin | R-HSA-68949 | 6.85 |
| CDT1 association with the CDC6:ORC:origin complex | R-HSA-68827 | 7.12 |
| Synthesis of DNA | R-HSA-69239 | 6.37 |
| E2F-enabled inhibition of pre-replication complex formation | R-HSA-113507 | 9.66 |
| Mitotic G1-G1/S phases | R-HSA-453279 | 5.91 |
| Assembly of the pre-replicative complex | R-HSA-68867 | 6.92 |
| G1/S Transition | R-HSA-69206 | 6.21 |
| DNA Replication Pre-Initiation | R-HSA-69002 | 6.62 |
| G2/M Checkpoints | R-HSA-69481 | 6.46 |
| S Phase | R-HSA-69242 | 6.02 |
| Unwinding of DNA | R-HSA-176974 | 9.4 |
| CDC6 association with the ORC:origin complex | R-HSA-68689 | 9.52 |
| DNA Replication | R-HSA-69306 | 6.25 |
| Regulation of DNA replication | R-HSA-69304 | 6.75 |
| Activation of ATR in response to replication stress | R-HSA-176187 | 7.77 |
| Removal of licensing factors from origins | R-HSA-69300 | 6.81 |
| E2F mediated regulation of DNA replication | R-HSA-113510 | 7.94 |
| M/G1 Transition | R-HSA-68874 | 6.62 |
| GO term | GO ID | GO IC |
|---|---|---|
| purine ribonucleoside triphosphate binding | GO:0035639 | 2.22 |
| binding | GO:0005488 | 0.18 |
| nucleic acid binding | GO:0003676 | 1.44 |
| DNA binding | GO:0003677 | 1.92 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| purine nucleoside binding | GO:0001883 | 2.22 |
| nucleoside binding | GO:0001882 | 2.21 |
| nucleotide binding | GO:0000166 | 1.96 |
| nucleoside phosphate binding | GO:1901265 | 1.96 |
| ribonucleoside binding | GO:0032549 | 2.22 |
| purine nucleotide binding | GO:0017076 | 2.19 |
| ATP binding | GO:0005524 | 2.43 |
| hydrolase activity | GO:0016787 | 1.9 |
| nucleoside-triphosphatase activity | GO:0017111 | 3.09 |
| helicase activity | GO:0004386 | 4.69 |
| small molecule binding | GO:0036094 | 1.89 |
| catalytic activity | GO:0003824 | 1.05 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | GO:0016818 | 3.03 |
| adenyl nucleotide binding | GO:0030554 | 2.4 |
| carbohydrate derivative binding | GO:0097367 | 2.03 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| hydrolase activity, acting on acid anhydrides | GO:0016817 | 3.03 |
| pyrophosphatase activity | GO:0016462 | 3.04 |
| adenyl ribonucleotide binding | GO:0032559 | 2.41 |
| protein binding | GO:0005515 | 0.46 |
| purine ribonucleotide binding | GO:0032555 | 2.2 |
| purine ribonucleoside binding | GO:0032550 | 2.22 |
| ribonucleotide binding | GO:0032553 | 2.19 |