Gene table of MUTYH : mutY DNA glycosylase

Gene-disease associations table

Disease IDDisease nameSource of annotation with MUTYHOMIM linkNumber of associated genesgenes
613659GASTRIC CANCEROMIM, HUMSAVAR link to OMIM 9KLF6, ERBB2, PIK3CA, APC, CASP10, IRF1, FGFR2, MUTYH, KRAS
PS175100FAMAILIAL ADENOMATOUS POLYPOSISClinVar, OMIM, HUMSAVAR link to OMIM 3APC, MUTYH, NTHL1
132600PILOMATRIXOMAOMIM link to OMIM 2CTNNB1, MUTYH

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Annotation of the gene MUTYH

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST
Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Base excision repairhsa034107.6
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Displacement of DNA glycosylase by APEX1R-HSA-1103579.81
Recognition and association of DNA glycosylase with site containing an affected purineR-HSA-11033011.4
Cleavage of the damaged purineR-HSA-11033111.4
DepurinationR-HSA-7392711.4
Resolution of Abasic Sites (AP sites)R-HSA-739337.85
DNA RepairR-HSA-738945.8
Base Excision RepairR-HSA-738847.85
Base-Excision Repair, AP Site FormationR-HSA-739299.66
Associated GO terms for Molecular function
GO termGO IDGO IC
hydrolase activity, hydrolyzing N-glycosyl compoundsGO:00167996.6
hydrolase activity, acting on glycosyl bondsGO:00167984.91
macromolecular complex bindingGO:00448772.61
bindingGO:00054880.18
nucleic acid bindingGO:00036761.44
DNA bindingGO:00036771.92
heterocyclic compound bindingGO:19013631.06
cation bindingGO:00431691.4
metal cluster bindingGO:00515405.55
ion bindingGO:00431671.36
MutSbeta complex bindingGO:00324089.74
protein complex bindingGO:00324033.09
metal ion bindingGO:00468721.41
MutSalpha complex bindingGO:00324078.13
MutLbeta complex bindingGO:00324069.74
MutLalpha complex bindingGO:00324057.95
mismatch repair complex bindingGO:00324047.66
hydrolase activityGO:00167871.9
DNA N-glycosylase activityGO:00191047.03
catalytic activityGO:00038241.05
4 iron, 4 sulfur cluster bindingGO:00515396.0
organic cyclic compound bindingGO:00971591.05
iron-sulfur cluster bindingGO:00515365.55
protein bindingGO:00055150.46