Disease ID | Disease name | Source of annotation with NGF | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
PS162400 | HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY | ClinVar, OMIM, HUMSAVAR | link to OMIM | 14 | DST, WNK1, NTRK1, PRDM12, DNMT1, IKBKAP, FAM134B, NGF, ATL1, KIF1A, SCN11A, ATL3, SPTLC2, SPTLC1 |
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KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
Rap1 signaling pathway | hsa04015 | 4.97 |
Ras signaling pathway | hsa04014 | 4.9 |
Inflammatory mediator regulation of TRP channels | hsa04750 | 6.07 |
MAPK signaling pathway | hsa04010 | 4.63 |
Neurotrophin signaling pathway | hsa04722 | 5.78 |
Apoptosis | hsa04210 | 6.23 |
PI3K-Akt signaling pathway | hsa04151 | 4.21 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
PI3K/AKT activation | R-HSA-198203 | 6.32 |
Frs2-mediated activation | R-HSA-170968 | 5.12 |
NFG and proNGF binds to p75NTR | R-HSA-205017 | 11.4 |
p75 NTR receptor-mediated signalling | R-HSA-193704 | 6.59 |
NRAGE signals death through JNK | R-HSA-193648 | 7.49 |
Ceramide signalling | R-HSA-193681 | 11.4 |
Signalling by NGF | R-HSA-166520 | 4.23 |
Signalling to p38 via RIT and RIN | R-HSA-187706 | 5.12 |
TRKA activation by NGF | R-HSA-187042 | 11.98 |
p75NTR recruits signalling complexes | R-HSA-209543 | 9.28 |
NF-kB is activated and signals survival | R-HSA-209560 | 9.28 |
Axonal growth stimulation | R-HSA-209563 | 10.98 |
Signalling to STAT3 | R-HSA-198745 | 11.4 |
NADE modulates death signalling | R-HSA-205025 | 10.4 |
p75NTR signals via NF-kB | R-HSA-193639 | 8.98 |
Signalling to RAS | R-HSA-167044 | 5.08 |
NRIF signals cell death from the nucleus | R-HSA-205043 | 9.08 |
NGF processing | R-HSA-167060 | 10.98 |
NGF signalling via TRKA from the plasma membrane | R-HSA-187037 | 4.51 |
Prolonged ERK activation events | R-HSA-169893 | 5.11 |
PLC-gamma1 signalling | R-HSA-167021 | 7.89 |
Activation of TRKA receptors | R-HSA-187015 | 10.4 |
p75NTR regulates axonogenesis | R-HSA-193697 | 9.66 |
Signalling to ERKs | R-HSA-187687 | 5.04 |
p75NTR negatively regulates cell cycle via SC1 | R-HSA-193670 | 10.4 |
ARMS-mediated activation | R-HSA-170984 | 5.12 |
Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 7.05 |
Retrograde neurotrophin signalling | R-HSA-177504 | 9.28 |
Signal Transduction | R-HSA-162582 | 1.78 |
GO term | GO ID | GO IC |
---|---|---|
cytokine receptor binding | GO:0005126 | 4.14 |
tumor necrosis factor receptor superfamily binding | GO:0032813 | 5.89 |
endopeptidase inhibitor activity | GO:0004866 | 4.6 |
death receptor binding | GO:0005123 | 6.91 |
nerve growth factor receptor binding | GO:0005163 | 9.74 |
enzyme regulator activity | GO:0030234 | 2.85 |
peptidase regulator activity | GO:0061134 | 4.37 |
receptor binding | GO:0005102 | 2.43 |
neurotrophin receptor binding | GO:0005165 | 7.17 |
peptidase inhibitor activity | GO:0030414 | 4.55 |
binding | GO:0005488 | 0.18 |
protein binding | GO:0005515 | 0.46 |
metalloendopeptidase inhibitor activity | GO:0008191 | 7.03 |
enzyme inhibitor activity | GO:0004857 | 3.78 |
molecular function regulator | GO:0098772 | 2.51 |
endopeptidase regulator activity | GO:0061135 | 4.57 |
growth factor activity | GO:0008083 | 4.66 |