Gene table of NLRC4 : NLR family CARD domain containing 4

Gene-disease associations table

Disease ID	Disease name	Source of annotation with NLRC4	OMIM link	Number of associated genes	genes
616050	AUTOINFLAMMATION WITH INFANTILE ENTEROCOLITIS	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	NLRC4
PS120100	FAMILIAL COLD AUTOINFLAMMATORY SYNDROME	ClinVar, OMIM, HUMSAVAR	link to OMIM	4	PLCG2, NLRP3, NLRP12, NLRC4

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Annotation of the gene NLRC4

Associated genes in ENSEMBL

ENSG00000091106

Associated proteins - SwissProt Accession ID

Q9NPP4

Associated PDB IDs

Cytogenetic Band

2p22.3

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

TP53

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Salmonella infection	hsa05132	6.29
NOD-like receptor signaling pathway	hsa04621	6.88
Legionellosis	hsa05134	6.88

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
The IPAF inflammasome	R-HSA-844623	11.98
Innate Immune System	R-HSA-168249	3.17
Immune System	R-HSA-168256	2.37
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	R-HSA-168643	7.31
Inflammasomes	R-HSA-622312	8.89

Associated GO terms for Molecular function

GO term	GO ID	GO IC
endopeptidase inhibitor activity	GO:0004866	4.6
purine ribonucleoside triphosphate binding	GO:0035639	2.22
binding	GO:0005488	0.18
enzyme inhibitor activity	GO:0004857	3.78
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
ubiquitin-like protein transferase activity	GO:0019787	3.69
cation binding	GO:0043169	1.4
molecular function regulator	GO:0098772	2.51
magnesium ion binding	GO:0000287	4.41
ion binding	GO:0043167	1.36
transferase activity	GO:0016740	1.95
nucleoside phosphate binding	GO:1901265	1.96
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
enzyme regulator activity	GO:0030234	2.85
ATP binding	GO:0005524	2.43
protein homodimerization activity	GO:0042803	3.16
endopeptidase regulator activity	GO:0061135	4.57
peptidase regulator activity	GO:0061134	4.37
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
peptidase inhibitor activity	GO:0030414	4.55
cysteine-type endopeptidase inhibitor activity	GO:0004869	5.71
ubiquitin-protein transferase activity	GO:0004842	3.73
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
adenyl ribonucleotide binding	GO:0032559	2.41
identical protein binding	GO:0042802	2.63
protein binding	GO:0005515	0.46
purine ribonucleotide binding	GO:0032555	2.2
protein dimerization activity	GO:0046983	2.72
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19