Gene table of NOD2 : nucleotide binding oligomerization domain containing 2

Gene-disease associations table

Disease IDDisease nameSource of annotation with NOD2OMIM linkNumber of associated genesgenes
PS266600INFLAMMATORY BOWEL DISEASEOMIM link to OMIM 10ATG16L1, IL10RB, IRGM, IL10RA, NOD2, IRF5, IL23R, ABCB1, SLC22A5, IL6
609464SARCOIDOSIS, EARLY-ONSETClinVar, OMIM, HUMSAVAR link to OMIM 1NOD2
186580BLAU SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 1NOD2
607507PSORIATIC ARTHRITIS, SUSCEPTIBILITY TOOMIM link to OMIM 2NOD2, LTA

Download the gene annotation in CSV format

Annotation of the gene NOD2

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
TNF signaling pathwayhsa046685.96
Shigellosishsa051316.74
Inflammatory bowel disease (IBD)hsa053216.43
NOD-like receptor signaling pathwayhsa046216.88
Tuberculosishsa051525.17
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
TRIF-mediated TLR3/TLR4 signaling R-HSA-9370616.47
Signaling by InterleukinsR-HSA-4491474.71
Toll Like Receptor 2 (TLR2) CascadeR-HSA-1814386.51
Immune SystemR-HSA-1682562.37
Toll Like Receptor TLR6:TLR2 CascadeR-HSA-1681886.56
Toll Like Receptor 5 (TLR5) CascadeR-HSA-1681766.73
Cytokine Signaling in Immune systemR-HSA-12802153.74
Toll Like Receptor 4 (TLR4) CascadeR-HSA-1660166.11
Toll Like Receptor 10 (TLR10) CascadeR-HSA-1681426.73
Toll Like Receptor 3 (TLR3) CascadeR-HSA-1681646.47
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysR-HSA-1686437.31
Toll-Like Receptors CascadesR-HSA-1688985.91
MyD88-independent TLR3/TLR4 cascade R-HSA-1661666.47
Interleukin-1 signalingR-HSA-4466527.52
activated TAK1 mediates p38 MAPK activationR-HSA-4503028.59
NOD1/2 Signaling PathwayR-HSA-1686387.85
Toll Like Receptor 7/8 (TLR7/8) CascadeR-HSA-1681816.68
Innate Immune SystemR-HSA-1682493.17
Toll Like Receptor TLR1:TLR2 CascadeR-HSA-1681796.51
TAK1 activates NFkB by phosphorylation and activation of IKKs complexR-HSA-4459898.08
MAP kinase activation in TLR cascadeR-HSA-4502947.28
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationR-HSA-9751386.72
MyD88 cascade initiated on plasma membraneR-HSA-9758716.73
MyD88 dependent cascade initiated on endosomeR-HSA-9751556.68
MyD88:Mal cascade initiated on plasma membraneR-HSA-1660586.56
Activated TLR4 signallingR-HSA-1660546.27
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1R-HSA-4503218.66
Toll Like Receptor 9 (TLR9) CascadeR-HSA-1681386.62
Associated GO terms for Molecular function
GO termGO IDGO IC
purine ribonucleoside triphosphate bindingGO:00356392.22
heat shock protein bindingGO:00310725.24
enzyme bindingGO:00198992.27
bindingGO:00054880.18
heterocyclic compound bindingGO:19013631.06
nucleoside phosphate bindingGO:19012651.96
nucleoside bindingGO:00018822.21
peptide bindingGO:00422774.22
Hsp70 protein bindingGO:00305446.37
CARD domain bindingGO:00507007.66
nucleotide bindingGO:00001661.96
actin bindingGO:00037793.74
purine nucleoside bindingGO:00018832.22
ribonucleoside bindingGO:00325492.22
purine nucleotide bindingGO:00170762.19
Hsp90 protein bindingGO:00518796.37
ATP bindingGO:00055242.43
muramyl dipeptide bindingGO:00325009.74
amide bindingGO:00332184.14
protein kinase bindingGO:00199013.44
kinase bindingGO:00199003.32
protein domain specific bindingGO:00199043.32
small molecule bindingGO:00360941.89
adenyl nucleotide bindingGO:00305542.4
carbohydrate derivative bindingGO:00973672.03
organic cyclic compound bindingGO:00971591.05
cytoskeletal protein bindingGO:00080923.02
peptidoglycan bindingGO:00428347.25
glycosaminoglycan bindingGO:00055394.42
adenyl ribonucleotide bindingGO:00325592.41
protein bindingGO:00055150.46
purine ribonucleotide bindingGO:00325552.2
purine ribonucleoside bindingGO:00325502.22
ribonucleotide bindingGO:00325532.19