Disease ID | Disease name | Source of annotation with NOD2 | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
PS266600 | INFLAMMATORY BOWEL DISEASE | OMIM | link to OMIM | 10 | ATG16L1, IL10RB, IRGM, IL10RA, NOD2, IRF5, IL23R, ABCB1, SLC22A5, IL6 |
609464 | SARCOIDOSIS, EARLY-ONSET | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | NOD2 |
186580 | BLAU SYNDROME | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | NOD2 |
607507 | PSORIATIC ARTHRITIS, SUSCEPTIBILITY TO | OMIM | link to OMIM | 2 | NOD2, LTA |
Download the gene annotation in CSV format
KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
TNF signaling pathway | hsa04668 | 5.96 |
Shigellosis | hsa05131 | 6.74 |
Inflammatory bowel disease (IBD) | hsa05321 | 6.43 |
NOD-like receptor signaling pathway | hsa04621 | 6.88 |
Tuberculosis | hsa05152 | 5.17 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
TRIF-mediated TLR3/TLR4 signaling | R-HSA-937061 | 6.47 |
Signaling by Interleukins | R-HSA-449147 | 4.71 |
Toll Like Receptor 2 (TLR2) Cascade | R-HSA-181438 | 6.51 |
Immune System | R-HSA-168256 | 2.37 |
Toll Like Receptor TLR6:TLR2 Cascade | R-HSA-168188 | 6.56 |
Toll Like Receptor 5 (TLR5) Cascade | R-HSA-168176 | 6.73 |
Cytokine Signaling in Immune system | R-HSA-1280215 | 3.74 |
Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 6.11 |
Toll Like Receptor 10 (TLR10) Cascade | R-HSA-168142 | 6.73 |
Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 6.47 |
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | R-HSA-168643 | 7.31 |
Toll-Like Receptors Cascades | R-HSA-168898 | 5.91 |
MyD88-independent TLR3/TLR4 cascade | R-HSA-166166 | 6.47 |
Interleukin-1 signaling | R-HSA-446652 | 7.52 |
activated TAK1 mediates p38 MAPK activation | R-HSA-450302 | 8.59 |
NOD1/2 Signaling Pathway | R-HSA-168638 | 7.85 |
Toll Like Receptor 7/8 (TLR7/8) Cascade | R-HSA-168181 | 6.68 |
Innate Immune System | R-HSA-168249 | 3.17 |
Toll Like Receptor TLR1:TLR2 Cascade | R-HSA-168179 | 6.51 |
TAK1 activates NFkB by phosphorylation and activation of IKKs complex | R-HSA-445989 | 8.08 |
MAP kinase activation in TLR cascade | R-HSA-450294 | 7.28 |
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | R-HSA-975138 | 6.72 |
MyD88 cascade initiated on plasma membrane | R-HSA-975871 | 6.73 |
MyD88 dependent cascade initiated on endosome | R-HSA-975155 | 6.68 |
MyD88:Mal cascade initiated on plasma membrane | R-HSA-166058 | 6.56 |
Activated TLR4 signalling | R-HSA-166054 | 6.27 |
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | R-HSA-450321 | 8.66 |
Toll Like Receptor 9 (TLR9) Cascade | R-HSA-168138 | 6.62 |
GO term | GO ID | GO IC |
---|---|---|
purine ribonucleoside triphosphate binding | GO:0035639 | 2.22 |
heat shock protein binding | GO:0031072 | 5.24 |
enzyme binding | GO:0019899 | 2.27 |
binding | GO:0005488 | 0.18 |
heterocyclic compound binding | GO:1901363 | 1.06 |
nucleoside phosphate binding | GO:1901265 | 1.96 |
nucleoside binding | GO:0001882 | 2.21 |
peptide binding | GO:0042277 | 4.22 |
Hsp70 protein binding | GO:0030544 | 6.37 |
CARD domain binding | GO:0050700 | 7.66 |
nucleotide binding | GO:0000166 | 1.96 |
actin binding | GO:0003779 | 3.74 |
purine nucleoside binding | GO:0001883 | 2.22 |
ribonucleoside binding | GO:0032549 | 2.22 |
purine nucleotide binding | GO:0017076 | 2.19 |
Hsp90 protein binding | GO:0051879 | 6.37 |
ATP binding | GO:0005524 | 2.43 |
muramyl dipeptide binding | GO:0032500 | 9.74 |
amide binding | GO:0033218 | 4.14 |
protein kinase binding | GO:0019901 | 3.44 |
kinase binding | GO:0019900 | 3.32 |
protein domain specific binding | GO:0019904 | 3.32 |
small molecule binding | GO:0036094 | 1.89 |
adenyl nucleotide binding | GO:0030554 | 2.4 |
carbohydrate derivative binding | GO:0097367 | 2.03 |
organic cyclic compound binding | GO:0097159 | 1.05 |
cytoskeletal protein binding | GO:0008092 | 3.02 |
peptidoglycan binding | GO:0042834 | 7.25 |
glycosaminoglycan binding | GO:0005539 | 4.42 |
adenyl ribonucleotide binding | GO:0032559 | 2.41 |
protein binding | GO:0005515 | 0.46 |
purine ribonucleotide binding | GO:0032555 | 2.2 |
purine ribonucleoside binding | GO:0032550 | 2.22 |
ribonucleotide binding | GO:0032553 | 2.19 |