Gene table of NR4A2 : nuclear receptor subfamily 4 group A member 2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with NR4A2	OMIM link	Number of associated genes	genes
PS168600	PARKINSON DISEASE	ClinVar	link to OMIM	30	ATP13A2, FGF20, VPS13C, DNAJC13, ATXN2, PINK1, CHCHD2, ADH1C, UCHL1, GIGYF2, SYNJ1, PODXL, HTRA2, LRRK2, TBP, PARK2, ATXN8OS, SNCAIP, GBA, SNCA, NR4A2, PLA2G6, GLUD2, PARK7, ATXN3, MAPT, DNAJC6, EIF4G1, FBXO7, VPS35

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Annotation of the gene NR4A2

Associated genes in ENSEMBL

ENSG00000153234

Associated proteins - SwissProt Accession ID

P43354

Associated PDB IDs

1ovl

Cytogenetic Band

2q24.1

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Nuclear Receptor transcription pathway	R-HSA-383280	7.31
Generic Transcription Pathway	R-HSA-212436	3.86
Gene Expression	R-HSA-74160	2.72

Associated GO terms for Molecular function

GO term	GO ID	GO IC
signaling receptor activity	GO:0038023	2.49
nucleic acid binding	GO:0003676	1.44
RNA polymerase II regulatory region DNA binding	GO:0001012	3.36
molecular transducer activity	GO:0060089	2.32
transcription factor activity, direct ligand regulated sequence-specific DNA binding	GO:0098531	5.87
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	GO:0001077	4.31
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
DNA binding	GO:0003677	1.92
heterocyclic compound binding	GO:1901363	1.06
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	GO:0004879	5.87
sequence-specific DNA binding	GO:0043565	2.79
sequence-specific double-stranded DNA binding	GO:1990837	3.2
transition metal ion binding	GO:0046914	2.48
ion binding	GO:0043167	1.36
identical protein binding	GO:0042802	2.63
receptor activity	GO:0004872	2.32
double-stranded DNA binding	GO:0003690	3.09
metal ion binding	GO:0046872	1.41
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	GO:0000982	3.94
RNA polymerase II transcription factor activity, sequence-specific DNA binding	GO:0000981	3.29
protein homodimerization activity	GO:0042803	3.16
glucocorticoid receptor binding	GO:0035259	6.97
steroid hormone receptor binding	GO:0035258	5.32
cation binding	GO:0043169	1.4
regulatory region nucleic acid binding	GO:0001067	3.03
transcription factor binding	GO:0008134	3.46
nuclear hormone receptor binding	GO:0035257	4.7
beta-catenin binding	GO:0008013	5.3
retinoid X receptor binding	GO:0046965	6.79
core promoter binding	GO:0001047	4.71
core promoter sequence-specific DNA binding	GO:0001046	5.12
hormone receptor binding	GO:0051427	4.57
protein dimerization activity	GO:0046983	2.72
transcription regulatory region DNA binding	GO:0044212	3.03
protein heterodimerization activity	GO:0046982	3.64
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
organic cyclic compound binding	GO:0097159	1.05
nucleic acid binding transcription factor activity	GO:0001071	2.65
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	GO:0001228	3.98
steroid hormone receptor activity	GO:0003707	5.66
transcription regulatory region sequence-specific DNA binding	GO:0000976	3.24
RNA polymerase II regulatory region sequence-specific DNA binding	GO:0000977	3.37
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
retinoic acid receptor binding	GO:0042974	5.83
receptor binding	GO:0005102	2.43
RNA polymerase II core promoter sequence-specific DNA binding	GO:0000979	5.77
zinc ion binding	GO:0008270	2.66