Gene table of NTRK2 : neurotrophic receptor tyrosine kinase 2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with NTRK2	OMIM link	Number of associated genes	genes
613886	OBESITY, HYPERPHAGIA, AND DEVELOPMENTAL DELAY	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	NTRK2

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Annotation of the gene NTRK2

Associated genes in ENSEMBL

ENSG00000148053

Associated proteins - SwissProt Accession ID

Q16620

Associated PDB IDs

Cytogenetic Band

9q21.33

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Neurotrophin signaling pathway	hsa04722	5.78
Alcoholism	hsa05034	5.59
MAPK signaling pathway	hsa04010	4.63

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Signal Transduction	R-HSA-162582	1.78
NGF-independant TRKA activation	R-HSA-187024	10.66
Activation of TRKA receptors	R-HSA-187015	10.4
Signalling by NGF	R-HSA-166520	4.23
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51

Associated GO terms for Molecular function

GO term	GO ID	GO IC
signaling receptor activity	GO:0038023	2.49
ribonucleotide binding	GO:0032553	2.19
purine ribonucleoside triphosphate binding	GO:0035639	2.22
brain-derived neurotrophic factor-activated receptor activity	GO:0060175	9.74
enzyme binding	GO:0019899	2.27
molecular transducer activity	GO:0060089	2.32
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
transmembrane receptor protein tyrosine kinase activity	GO:0004714	5.55
receptor tyrosine kinase binding	GO:0030971	5.77
growth factor binding	GO:0019838	4.89
nucleotide binding	GO:0000166	1.96
transferase activity	GO:0016740	1.95
neurotrophin receptor activity	GO:0005030	8.35
protein tyrosine kinase activity	GO:0004713	4.54
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
protein kinase activity	GO:0004672	3.27
protein tyrosine kinase binding	GO:1990782	5.7
neurotrophin binding	GO:0043121	7.44
identical protein binding	GO:0042802	2.63
protein homodimerization activity	GO:0042803	3.16
kinase activity	GO:0016301	2.93
nucleoside phosphate binding	GO:1901265	1.96
protein kinase binding	GO:0019901	3.44
kinase binding	GO:0019900	3.32
receptor binding	GO:0005102	2.43
small molecule binding	GO:0036094	1.89
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
catalytic activity	GO:0003824	1.05
brain-derived neurotrophic factor binding	GO:0048403	8.64
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
transmembrane signaling receptor activity	GO:0004888	2.57
adenyl ribonucleotide binding	GO:0032559	2.41
ATP binding	GO:0005524	2.43
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
protein dimerization activity	GO:0046983	2.72
transmembrane receptor protein kinase activity	GO:0019199	5.32
purine ribonucleoside binding	GO:0032550	2.22
transmembrane receptor activity	GO:0099600	2.53
receptor activity	GO:0004872	2.32