Gene table of P2RX1 : purinergic receptor P2X 1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with P2RX1	OMIM link	Number of associated genes	genes
PS231200	BLEEDING DISORDER, PLATELET-TYPE	OMIM	link to OMIM	21	NBEAL2, ANO6, GP1BA, ITGA2, GFI1B, ITGA2B, PLAU, PRKACG, P2RY12, ACTN1, TBXAS1, P2RX1, GP6, CD36, SLFN14, ITGB3, GP9, GP1BB, RASGRP2, TBXA2R, MYH9

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Annotation of the gene P2RX1

Associated genes in ENSEMBL

ENSG00000108405

Associated proteins - SwissProt Accession ID

P51575

Associated PDB IDs

Cytogenetic Band

17p13.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Platelet activation	hsa04611	5.66
Calcium signaling pathway	hsa04020	5.22
Neuroactive ligand-receptor interaction	hsa04080	4.58

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Elevation of cytosolic Ca2+ levels	R-HSA-139853	9.81
Platelet calcium homeostasis	R-HSA-418360	8.73
Platelet homeostasis	R-HSA-418346	6.68
Hemostasis	R-HSA-109582	3.98

Associated GO terms for Molecular function

GO term	GO ID	GO IC
cation channel activity	GO:0005261	4.04
purine ribonucleoside triphosphate binding	GO:0035639	2.22
heterocyclic compound binding	GO:1901363	1.06
drug binding	GO:0008144	5.03
molecular transducer activity	GO:0060089	2.32
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
signaling receptor activity	GO:0038023	2.49
nucleotide binding	GO:0000166	1.96
transmembrane receptor activity	GO:0099600	2.53
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
extracellular ATP-gated cation channel activity	GO:0004931	7.79
transition metal ion binding	GO:0046914	2.48
zinc ion binding	GO:0008270	2.66
ligand-gated ion channel activity	GO:0015276	4.8
ion binding	GO:0043167	1.36
purinergic receptor activity	GO:0035586	6.52
nucleoside phosphate binding	GO:1901265	1.96
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
extracellular ligand-gated ion channel activity	GO:0005230	5.42
ATP binding	GO:0005524	2.43
ATP-gated ion channel activity	GO:0035381	7.79
substrate-specific transmembrane transporter activity	GO:0022891	2.9
cation transmembrane transporter activity	GO:0008324	3.32
transmembrane transporter activity	GO:0022857	2.82
transporter activity	GO:0005215	2.57
ion channel activity	GO:0005216	3.71
excitatory extracellular ligand-gated ion channel activity	GO:0005231	5.73
small molecule binding	GO:0036094	1.89
passive transmembrane transporter activity	GO:0022803	3.6
purinergic nucleotide receptor activity	GO:0001614	6.69
substrate-specific transporter activity	GO:0022892	2.72
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
nucleotide receptor activity	GO:0016502	6.69
ion transmembrane transporter activity	GO:0015075	3.04
transmembrane signaling receptor activity	GO:0004888	2.57
channel activity	GO:0015267	3.6
adenyl ribonucleotide binding	GO:0032559	2.41
gated channel activity	GO:0022836	3.96
ligand-gated channel activity	GO:0022834	4.8
purine ribonucleotide binding	GO:0032555	2.2
substrate-specific channel activity	GO:0022838	3.67
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
receptor activity	GO:0004872	2.32