Gene table of PAX8 : paired box 8

Gene-disease associations table

Disease IDDisease nameSource of annotation with PAX8OMIM linkNumber of associated genesgenes
PS275200HYPOTHYROIDISM, CONGENITAL, NONGOITROUSClinVar, OMIM, HUMSAVAR link to OMIM 5PAX8, THRA, NKX2-5, TSHB, TSHR

Download the gene annotation in CSV format

Annotation of the gene PAX8

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is a TF of the genes:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Thyroid hormone synthesishsa049186.56
Thyroid cancerhsa052167.48
Pathways in cancerhsa052003.98
Transcriptional misregulation in cancerhsa052025.21
Associated REACTOME pathways
Associated GO terms for Molecular function
GO termGO IDGO IC
signaling receptor activityGO:00380232.49
nucleic acid bindingGO:00036761.44
RNA polymerase II regulatory region DNA bindingGO:00010123.36
core promoter proximal region DNA bindingGO:00011593.82
molecular transducer activityGO:00600892.32
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingGO:00010774.31
receptor activityGO:00048722.32
bindingGO:00054880.18
signal transducer activityGO:00048712.28
DNA bindingGO:00036771.92
heterocyclic compound bindingGO:19013631.06
sequence-specific DNA bindingGO:00435652.79
G-protein coupled receptor activityGO:00049302.95
sequence-specific double-stranded DNA bindingGO:19908373.2
core promoter proximal region sequence-specific DNA bindingGO:00009873.83
double-stranded DNA bindingGO:00036903.09
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific bindingGO:00009823.94
RNA polymerase II transcription factor activity, sequence-specific DNA bindingGO:00009813.29
regulatory region nucleic acid bindingGO:00010673.03
core promoter bindingGO:00010474.71
core promoter sequence-specific DNA bindingGO:00010465.12
thyroid-stimulating hormone receptor activityGO:00049969.05
transcription regulatory region DNA bindingGO:00442123.03
transcription factor activity, sequence-specific DNA bindingGO:00037002.65
organic cyclic compound bindingGO:00971591.05
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingGO:00012283.98
transmembrane signaling receptor activityGO:00048882.57
transcription regulatory region sequence-specific DNA bindingGO:00009763.24
RNA polymerase II regulatory region sequence-specific DNA bindingGO:00009773.37
protein bindingGO:00055150.46
regulatory region DNA bindingGO:00009753.03
RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009783.88
RNA polymerase II core promoter sequence-specific DNA bindingGO:00009795.77
protein-hormone receptor activityGO:00165007.17
transmembrane receptor activityGO:00996002.53
nucleic acid binding transcription factor activityGO:00010712.65