Gene table of PCNA : proliferating cell nuclear antigen

Gene-disease associations table

Disease IDDisease nameSource of annotation with PCNAOMIM linkNumber of associated genesgenes

Download the gene annotation in CSV format

Annotation of the gene PCNA

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
Base excision repairhsa034107.6
Hepatitis Bhsa051615.52
DNA replicationhsa030307.48
Mismatch repairhsa034308.07
Nucleotide excision repairhsa034207.15
HTLV-I infectionhsa051664.59
Cell cyclehsa041105.68
Associated REACTOME pathways
Global Genomic NER (GG-NER)R-HSA-1099707.89
Translesion Synthesis by POLHR-HSA-1103208.73
Leading Strand SynthesisR-HSA-691099.18
Gap-filling DNA repair synthesis and ligation in TC-NERR-HSA-1099798.98
Transcription-coupled NER (TC-NER)R-HSA-739377.49
Resolution of Abasic Sites (AP sites)R-HSA-739337.85
Cell CycleR-HSA-16401703.89
Translesion synthesis by POLKR-HSA-56558628.89
G0 and Early G1R-HSA-15381338.34
Repair synthesis for gap-filling by DNA polymerase in TC-NERR-HSA-1099779.08
DNA ReplicationR-HSA-693066.25
Translesion synthesis by POLIR-HSA-56561218.89
Gap-filling DNA repair synthesis and ligation in GG-NERR-HSA-749698.98
DNA strand elongationR-HSA-691907.94
Cell Cycle, MitoticR-HSA-692784.16
Polymerase switchingR-HSA-690919.18
Chromosome MaintenanceR-HSA-738866.56
Nucleotide Excision RepairR-HSA-738857.34
Base Excision RepairR-HSA-738847.85
Resolution of AP sites via the multiple-nucleotide patch replacement pathwayR-HSA-1103738.52
Synthesis of DNAR-HSA-692396.37
Mitotic G1-G1/S phasesR-HSA-4532795.91
Repair synthesis of patch ~27-30 bases long by DNA polymeraseR-HSA-749679.08
Recognition of DNA damage by PCNA-containing replication complexR-HSA-1103148.18
Processive synthesis on the C-strand of the telomereR-HSA-1744149.4
Telomere C-strand (Lagging Strand) SynthesisR-HSA-1744178.46
Telomere MaintenanceR-HSA-1575797.1
Translesion synthesis by REV1R-HSA-1103128.98
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateR-HSA-1103137.77
Removal of the Flap Intermediate from the C-strandR-HSA-1744379.66
Mismatch RepairR-HSA-53585089.08
Removal of the Flap IntermediateR-HSA-691669.18
Polymerase switching on the C-strand of the telomereR-HSA-1744119.18
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)R-HSA-53586069.18
E2F mediated regulation of DNA replicationR-HSA-1135107.94
G1/S TransitionR-HSA-692066.21
G1/S-Specific TranscriptionR-HSA-692058.89
Extension of TelomeresR-HSA-1807868.12
Termination of translesion DNA synthesisR-HSA-56561698.08
S PhaseR-HSA-692426.02
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)R-HSA-53585659.18
PCNA-Dependent Long Patch Base Excision RepairR-HSA-56518018.73
DNA RepairR-HSA-738945.8
Lagging Strand SynthesisR-HSA-691868.59
Processive synthesis on the lagging strandR-HSA-691838.98
DNA Damage BypassR-HSA-738937.46
Associated GO terms for Molecular function
hydrolase activity, hydrolyzing N-glycosyl compoundsGO:00167996.6
hydrolase activity, acting on glycosyl bondsGO:00167984.91
enzyme bindingGO:00198992.27
mismatched DNA bindingGO:00309837.25
macromolecular complex bindingGO:00448772.61
nucleic acid bindingGO:00036761.44
DNA bindingGO:00036771.92
molecular function regulatorGO:00987722.51
heterocyclic compound bindingGO:19013631.06
DNA polymerase bindingGO:00701827.25
purine-specific mismatch base pair DNA N-glycosylase activityGO:00007019.74
mismatch base pair DNA N-glycosylase activityGO:00007008.64
receptor tyrosine kinase bindingGO:00309715.77
dinucleotide insertion or deletion bindingGO:00321398.64
protein complex bindingGO:00324033.09
double-stranded DNA bindingGO:00036903.09
protein tyrosine kinase bindingGO:19907825.7
identical protein bindingGO:00428022.63
mismatch repair complex bindingGO:00324047.66
DNA polymerase processivity factor activityGO:00303379.05
hydrolase activityGO:00167871.9
steroid hormone receptor bindingGO:00352585.32
estrogen receptor bindingGO:00303316.05
enzyme regulator activityGO:00302342.85
nuclear hormone receptor bindingGO:00352574.7
DNA N-glycosylase activityGO:00191047.03
histone acetyltransferase bindingGO:00350356.41
protein kinase bindingGO:00199013.44
kinase bindingGO:00199003.32
hormone receptor bindingGO:00514274.57
DNA insertion or deletion bindingGO:00321357.95
catalytic activityGO:00038241.05
organic cyclic compound bindingGO:00971591.05
MutLalpha complex bindingGO:00324057.95
protein bindingGO:00055150.46
receptor bindingGO:00051022.43
chromatin bindingGO:00036823.64
damaged DNA bindingGO:00036845.58