| Disease ID | Disease name | Source of annotation with PLA2G2A | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 114500 | COLORECTAL CANCER | OMIM | link to OMIM | 30 | TLR4, RAD54B, PTPRJ, TP53, EP300, PTPN12, ODC1, FLCN, TLR2, BAX, PLA2G2A, AURKA, NRAS, APC, MCC, TRIM28, MLH3, AKT1, MT-CO1, AXIN2, CTNNB1, PDGFRL, PIK3CA, KAT5, DCC, BRAF, CCND1, FGFR3, DLC1, BUB1B |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Pancreatic secretion | hsa04972 | 6.07 |
| Fat digestion and absorption | hsa04975 | 7.45 |
| Ether lipid metabolism | hsa00565 | 7.28 |
| Glycerophospholipid metabolism | hsa00564 | 6.15 |
| alpha-Linolenic acid metabolism | hsa00592 | 8.12 |
| Arachidonic acid metabolism | hsa00590 | 6.79 |
| Linoleic acid metabolism | hsa00591 | 7.91 |
| Ras signaling pathway | hsa04014 | 4.9 |
| Metabolic pathways | hsa01100 | 2.49 |
| Vascular smooth muscle contraction | hsa04270 | 5.74 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Phospholipid metabolism | R-HSA-1483257 | 5.83 |
| Synthesis of PA | R-HSA-1483166 | 8.18 |
| Acyl chain remodelling of PE | R-HSA-1482839 | 8.46 |
| Acyl chain remodelling of PS | R-HSA-1482801 | 8.89 |
| Acyl chain remodelling of PG | R-HSA-1482925 | 8.89 |
| Glycerophospholipid biosynthesis | R-HSA-1483206 | 6.46 |
| Metabolism | R-HSA-1430728 | 2.34 |
| Acyl chain remodelling of PI | R-HSA-1482922 | 8.98 |
| Acyl chain remodelling of PC | R-HSA-1482788 | 8.34 |
| Metabolism of lipids and lipoproteins | R-HSA-556833 | 3.79 |
| GO term | GO ID | GO IC |
|---|---|---|
| hydrolase activity | GO:0016787 | 1.9 |
| calcium-dependent phospholipase A2 activity | GO:0047498 | 7.54 |
| carboxylic ester hydrolase activity | GO:0052689 | 4.81 |
| phospholipid binding | GO:0005543 | 3.91 |
| lipid binding | GO:0008289 | 3.26 |
| hydrolase activity, acting on ester bonds | GO:0016788 | 3.1 |
| ion binding | GO:0043167 | 1.36 |
| catalytic activity | GO:0003824 | 1.05 |
| cation binding | GO:0043169 | 1.4 |
| binding | GO:0005488 | 0.18 |
| phospholipase A2 activity | GO:0004623 | 6.24 |
| phospholipase activity | GO:0004620 | 5.16 |
| metal ion binding | GO:0046872 | 1.41 |
| lipase activity | GO:0016298 | 4.96 |
| calcium ion binding | GO:0005509 | 3.17 |