| Disease ID | Disease name | Source of annotation with PLA2G6 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS168600 | PARKINSON DISEASE | ClinVar, OMIM, HUMSAVAR | link to OMIM | 30 | ATP13A2, FGF20, VPS13C, DNAJC13, ATXN2, PINK1, CHCHD2, ADH1C, UCHL1, GIGYF2, SYNJ1, PODXL, HTRA2, LRRK2, TBP, PARK2, ATXN8OS, SNCAIP, GBA, SNCA, NR4A2, PLA2G6, GLUD2, PARK7, ATXN3, MAPT, DNAJC6, EIF4G1, FBXO7, VPS35 |
| PS234200 | NEURODEGENERATION WITH BRAIN IRON ACCUMULATION | ClinVar, OMIM, HUMSAVAR | link to OMIM | 6 | FTL, COASY, PANK2, WDR45, C19orf12, PLA2G6 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Ether lipid metabolism | hsa00565 | 7.28 |
| Glycerophospholipid metabolism | hsa00564 | 6.15 |
| alpha-Linolenic acid metabolism | hsa00592 | 8.12 |
| Arachidonic acid metabolism | hsa00590 | 6.79 |
| Linoleic acid metabolism | hsa00591 | 7.91 |
| Ras signaling pathway | hsa04014 | 4.9 |
| Inflammatory mediator regulation of TRP channels | hsa04750 | 6.07 |
| Fc gamma R-mediated phagocytosis | hsa04666 | 6.21 |
| Metabolic pathways | hsa01100 | 2.49 |
| Vascular smooth muscle contraction | hsa04270 | 5.74 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Acyl chain remodelling of PE | R-HSA-1482839 | 8.46 |
| Fcgamma receptor (FCGR) dependent phagocytosis | R-HSA-2029480 | 5.07 |
| Role of phospholipids in phagocytosis | R-HSA-2029485 | 5.47 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Immune System | R-HSA-168256 | 2.37 |
| Phospholipid metabolism | R-HSA-1483257 | 5.83 |
| Acyl chain remodeling of CL | R-HSA-1482798 | 10.4 |
| Glycerophospholipid biosynthesis | R-HSA-1483206 | 6.46 |
| Metabolism | R-HSA-1430728 | 2.34 |
| Acyl chain remodelling of PC | R-HSA-1482788 | 8.34 |
| Metabolism of lipids and lipoproteins | R-HSA-556833 | 3.79 |
| GO term | GO ID | GO IC |
|---|---|---|
| hydrolase activity | GO:0016787 | 1.9 |
| enzyme binding | GO:0019899 | 2.27 |
| calcium-independent phospholipase A2 activity | GO:0047499 | 8.13 |
| hydrolase activity, acting on ester bonds | GO:0016788 | 3.1 |
| catalytic activity | GO:0003824 | 1.05 |
| carboxylic ester hydrolase activity | GO:0052689 | 4.81 |
| protein kinase binding | GO:0019901 | 3.44 |
| kinase binding | GO:0019900 | 3.32 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| phospholipase A2 activity | GO:0004623 | 6.24 |
| phospholipase activity | GO:0004620 | 5.16 |
| ATP-dependent protein binding | GO:0043008 | 7.66 |
| lipase activity | GO:0016298 | 4.96 |
| calmodulin binding | GO:0005516 | 4.55 |