| Disease ID | Disease name | Source of annotation with PLCB4 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS602483 | AURICULOCONDYLAR SYNDROME | ClinVar, OMIM, HUMSAVAR | link to OMIM | 3 | GNAI3, EDN1, PLCB4 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Platelet activation | hsa04611 | 5.66 |
| cGMP-PKG signaling pathway | hsa04022 | 5.32 |
| Calcium signaling pathway | hsa04020 | 5.22 |
| Long-term potentiation | hsa04720 | 6.64 |
| Retrograde endocannabinoid signaling | hsa04723 | 6.03 |
| Cholinergic synapse | hsa04725 | 5.88 |
| Glutamatergic synapse | hsa04724 | 5.84 |
| Serotonergic synapse | hsa04726 | 5.84 |
| Dopaminergic synapse | hsa04728 | 5.69 |
| Chemokine signaling pathway | hsa04062 | 5.19 |
| Oxytocin signaling pathway | hsa04921 | 5.4 |
| Inositol phosphate metabolism | hsa00562 | 6.72 |
| Endocrine and other factor-regulated calcium reabsorption | hsa04961 | 7.12 |
| Circadian entrainment | hsa04713 | 6.11 |
| Chagas disease (American trypanosomiasis) | hsa05142 | 5.99 |
| African trypanosomiasis | hsa05143 | 7.68 |
| Amoebiasis | hsa05146 | 5.82 |
| Wnt signaling pathway | hsa04310 | 5.49 |
| Vascular smooth muscle contraction | hsa04270 | 5.74 |
| Gap junction | hsa04540 | 6.24 |
| Pathways in cancer | hsa05200 | 3.98 |
| GnRH signaling pathway | hsa04912 | 6.18 |
| Phosphatidylinositol signaling system | hsa04070 | 6.38 |
| Rap1 signaling pathway | hsa04015 | 4.97 |
| Insulin secretion | hsa04911 | 6.18 |
| Melanogenesis | hsa04916 | 5.97 |
| Estrogen signaling pathway | hsa04915 | 6.11 |
| Thyroid hormone synthesis | hsa04918 | 6.56 |
| Thyroid hormone signaling pathway | hsa04919 | 5.82 |
| Long-term depression | hsa04730 | 6.74 |
| Salivary secretion | hsa04970 | 6.23 |
| Gastric acid secretion | hsa04971 | 6.48 |
| Pancreatic secretion | hsa04972 | 6.07 |
| Metabolic pathways | hsa01100 | 2.49 |
| Inflammatory mediator regulation of TRP channels | hsa04750 | 6.07 |
| Huntington's disease | hsa05016 | 5.17 |
| Alzheimer's disease | hsa05010 | 5.34 |
| Adrenergic signaling in cardiomyocytes | hsa04261 | 5.44 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Inositol phosphate metabolism | R-HSA-1483249 | 7.52 |
| Synthesis of IP3 and IP4 in the cytosol | R-HSA-1855204 | 8.34 |
| G-protein mediated events | R-HSA-112040 | 7.49 |
| GPCR downstream signaling | R-HSA-388396 | 3.07 |
| Opioid Signalling | R-HSA-111885 | 6.64 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 4.26 |
| G alpha (q) signalling events | R-HSA-416476 | 5.42 |
| Metabolism | R-HSA-1430728 | 2.34 |
| Signaling by GPCR | R-HSA-372790 | 2.68 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| PLC beta mediated events | R-HSA-112043 | 7.52 |
| GO term | GO ID | GO IC |
|---|---|---|
| protein kinase binding | GO:0019901 | 3.44 |
| mitogen-activated protein kinase binding | GO:0051019 | 6.56 |
| signal transducer activity | GO:0004871 | 2.28 |
| hydrolase activity | GO:0016787 | 1.9 |
| phosphatidylinositol phospholipase C activity | GO:0004435 | 6.41 |
| catalytic activity | GO:0003824 | 1.05 |
| cation binding | GO:0043169 | 1.4 |
| enzyme binding | GO:0019899 | 2.27 |
| hydrolase activity, acting on ester bonds | GO:0016788 | 3.1 |
| ion binding | GO:0043167 | 1.36 |
| phosphoric ester hydrolase activity | GO:0042578 | 3.82 |
| kinase binding | GO:0019900 | 3.32 |
| phospholipase C activity | GO:0004629 | 6.3 |
| phosphoric diester hydrolase activity | GO:0008081 | 5.23 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| phospholipase activity | GO:0004620 | 5.16 |
| metal ion binding | GO:0046872 | 1.41 |
| lipase activity | GO:0016298 | 4.96 |
| calcium ion binding | GO:0005509 | 3.17 |