Gene table of PLEKHG2 : pleckstrin homology and RhoGEF domain containing G2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with PLEKHG2	OMIM link	Number of associated genes	genes
616763	LEUKODYSTROPHY AND ACQUIRED MICROCEPHALY WITH OR WITHOUT DYSTONIA	OMIM	link to OMIM	1	PLEKHG2

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
p75 NTR receptor-mediated signalling	R-HSA-193704	6.59
Signalling by NGF	R-HSA-166520	4.23
G alpha (12/13) signalling events	R-HSA-416482	6.75
GPCR downstream signaling	R-HSA-388396	3.07
Signaling by Rho GTPases	R-HSA-194315	4.43
Rho GTPase cycle	R-HSA-194840	6.04
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	7.05
Signaling by GPCR	R-HSA-372790	2.68
Signal Transduction	R-HSA-162582	1.78
NRAGE signals death through JNK	R-HSA-193648	7.49

Associated GO terms for Molecular function

GO term	GO ID	GO IC
Rho guanyl-nucleotide exchange factor activity	GO:0005089	5.37
Ras guanyl-nucleotide exchange factor activity	GO:0005088	4.31
guanyl-nucleotide exchange factor activity	GO:0005085	4.02
binding	GO:0005488	0.18
protein binding	GO:0005515	0.46
molecular function regulator	GO:0098772	2.51