Gene table of PPP2R1A : protein phosphatase 2 scaffold subunit Aalpha

Gene-disease associations table

Disease IDDisease nameSource of annotation with PPP2R1AOMIM linkNumber of associated genesgenes
PS156200MENTAL RETARDATION, AUTOSOMAL DOMINANTClinVar, OMIM, HUMSAVAR link to OMIM 44EHMT1, KANSL1, AHDC1, SOX11, CDH15, KIRREL3, EEF1A2, KAT6A, ZMYND11, ARID1A, KMT2C, PPP2R5D, DYNC1H1, GRIN1, CTCF, SETD5, AUTS2, PACS1, DPP6, MBD5, DEAF1, KIF1A, SYNGAP1, PURA, POGZ, EPB41L1, PPP2R1A, NR1I3, CTNNB1, ARID1B, MYT1L, CACNG2, COL4A3BP, SMARCB1, MEF2C, SMARCE1, SMARCA4, ZBTB18, ADNP, GATAD2B, SETBP1, GRIN2B, CHAMP1, DYRK1A

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Annotation of the gene PPP2R1A

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST
Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
TGF-beta signaling pathwayhsa043506.41
Chagas disease (American trypanosomiasis)hsa051425.99
Hepatitis Chsa051605.68
Oocyte meiosishsa041145.91
Tight junctionhsa045305.53
mRNA surveillance pathwayhsa030156.28
Hippo signaling pathwayhsa043905.37
Dopaminergic synapsehsa047285.69
AMPK signaling pathwayhsa041525.8
Adrenergic signaling in cardiomyocyteshsa042615.44
Long-term depressionhsa047306.74
PI3K-Akt signaling pathwayhsa041514.21
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Glucose metabolismR-HSA-703266.77
Toll Like Receptor 4 (TLR4) CascadeR-HSA-1660166.11
Cell CycleR-HSA-16401703.89
Developmental BiologyR-HSA-12667383.48
Recruitment of mitotic centrosome proteins and complexesR-HSA-3802706.68
Signaling by VEGFR-HSA-1941384.66
Organelle biogenesis and maintenanceR-HSA-18522414.63
FCERI mediated MAPK activationR-HSA-28717964.32
Toll Like Receptor 3 (TLR3) CascadeR-HSA-1681646.47
Beta-catenin phosphorylation cascadeR-HSA-1962998.89
Signaling by EGFRR-HSA-1779294.59
AXIN mutants destabilize the destruction complex, activating WNT signalingR-HSA-48397359.18
Platelet homeostasisR-HSA-4183466.68
Nuclear Events (kinase and transcription factor activation)R-HSA-1987258.4
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
Spry regulation of FGF signalingR-HSA-12955969.18
Interleukin-2 signalingR-HSA-4519275.05
MAP kinase activation in TLR cascadeR-HSA-4502947.28
MyD88-independent TLR3/TLR4 cascade R-HSA-1661666.47
truncations of AMER1 destabilize the destruction complexR-HSA-54673489.18
Toll Like Receptor TLR1:TLR2 CascadeR-HSA-1681796.51
misspliced GSK3beta mutants stabilize beta-cateninR-HSA-53397169.08
S33 mutants of beta-catenin aren't phosphorylatedR-HSA-53587479.08
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)R-HSA-9759576.25
Toll Like Receptor 5 (TLR5) CascadeR-HSA-1681766.73
S37 mutants of beta-catenin aren't phosphorylatedR-HSA-53587499.08
FRS-mediated FGFR4 signalingR-HSA-56547125.14
Downstream signaling of activated FGFR4R-HSA-56547164.71
Signaling by ERBB2R-HSA-12279864.66
VEGFR2 mediated cell proliferationR-HSA-52189215.07
Opioid SignallingR-HSA-1118856.64
ERK/MAPK targetsR-HSA-1987538.59
Immune SystemR-HSA-1682562.37
Frs2-mediated activationR-HSA-1709685.12
Downstream signal transductionR-HSA-1867634.65
Loss of Nlp from mitotic centrosomesR-HSA-3802597.03
RAF activationR-HSA-56730008.34
RAF/MAP kinase cascadeR-HSA-56730015.15
T41 mutants of beta-catenin aren't phosphorylatedR-HSA-53587529.08
MAPK targets/ Nuclear events mediated by MAP kinasesR-HSA-4502828.08
Toll Like Receptor 10 (TLR10) CascadeR-HSA-1681426.73
Mitotic Metaphase and AnaphaseR-HSA-25553965.45
Signalling to p38 via RIT and RINR-HSA-1877065.12
CTLA4 inhibitory signalingR-HSA-3895138.52
FRS-mediated FGFR2 signalingR-HSA-56547005.14
Cell Cycle, MitoticR-HSA-692784.16
FRS-mediated FGFR3 signalingR-HSA-56547065.14
Cyclin A/B1 associated events during G2/M transitionR-HSA-692738.52
Downstream signaling of activated FGFR3R-HSA-56547084.71
G2/M TransitionR-HSA-692756.06
Mitotic G1-G1/S phasesR-HSA-4532795.91
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
G1/S TransitionR-HSA-692066.21
Interleukin receptor SHC signalingR-HSA-9125265.09
Innate Immune SystemR-HSA-1682493.17
Mitotic G2-G2/M phasesR-HSA-4532746.04
Integration of energy metabolismR-HSA-1636856.24
TCF dependent signaling in response to WNTR-HSA-2016815.36
Anchoring of the basal body to the plasma membraneR-HSA-56209126.51
Mitotic AnaphaseR-HSA-688825.46
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
Prolonged ERK activation eventsR-HSA-1698935.11
Signaling by WntR-HSA-1957214.79
Signaling by FGFR2R-HSA-56547384.68
GRB2 events in EGFR signalingR-HSA-1798125.15
Signaling by FGFR1R-HSA-56547364.69
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationR-HSA-9751386.72
Negative regulation of FGFR4 signalingR-HSA-56547338.03
MyD88 cascade initiated on plasma membraneR-HSA-9758716.73
DAP12 interactionsR-HSA-21721274.56
ERKs are inactivatedR-HSA-2026709.4
Axon guidanceR-HSA-4224753.93
Nonsense-Mediated Decay (NMD)R-HSA-9278026.25
Mitotic PrometaphaseR-HSA-688776.08
Mitotic ProphaseR-HSA-688756.27
TRIF-mediated TLR3/TLR4 signaling R-HSA-9370616.47
Toll Like Receptor 2 (TLR2) CascadeR-HSA-1814386.51
Signaling by LeptinR-HSA-25865525.1
IGF1R signaling cascadeR-HSA-24289244.85
IRS-related events triggered by IGF1RR-HSA-24289284.85
M PhaseR-HSA-688864.87
IRS-mediated signallingR-HSA-1123994.87
Signaling by Insulin receptorR-HSA-747524.73
DiseaseR-HSA-16436853.33
Insulin receptor signalling cascadeR-HSA-747514.85
Downstream signaling of activated FGFR1R-HSA-56546874.71
Metabolism of carbohydratesR-HSA-713874.93
MASTL Facilitates Mitotic ProgressionR-HSA-24659109.66
Gene ExpressionR-HSA-741602.72
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
Negative regulation of FGFR1 signalingR-HSA-56547267.98
Negative regulation of FGFR2 signalingR-HSA-56547277.89
Toll-Like Receptors CascadesR-HSA-1688985.91
Inhibition of replication initiation of damaged DNA by RB1/E2F1R-HSA-1135019.4
Toll Like Receptor TLR6:TLR2 CascadeR-HSA-1681886.56
Diseases of signal transductionR-HSA-56632024.89
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Toll Like Receptor 7/8 (TLR7/8) CascadeR-HSA-1681816.68
Signalling to RASR-HSA-1670445.08
GlycolysisR-HSA-701718.03
Downstream signaling of activated FGFR2R-HSA-56546964.71
SHC1 events in EGFR signalingR-HSA-1803365.15
FRS-mediated FGFR1 signalingR-HSA-56546935.14
APC truncation mutants have impaired AXIN bindingR-HSA-54673379.18
SHC1 events in ERBB2 signalingR-HSA-12501965.15
Signaling by WNT in cancerR-HSA-47912757.89
ARMS-mediated activationR-HSA-1709845.12
PP2A-mediated dephosphorylation of key metabolic factorsR-HSA-16376710.18
MyD88 dependent cascade initiated on endosomeR-HSA-9751556.68
MyD88:Mal cascade initiated on plasma membraneR-HSA-1660586.56
Signalling to ERKsR-HSA-1876875.04
Signaling by PDGFR-HSA-1867974.53
Activated TLR4 signallingR-HSA-1660546.27
E2F mediated regulation of DNA replicationR-HSA-1135107.94
Regulation of PLK1 Activity at G2/M TransitionR-HSA-25659426.66
Toll Like Receptor 9 (TLR9) CascadeR-HSA-1681386.62
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Separation of Sister ChromatidsR-HSA-24678135.55
Signaling by InterleukinsR-HSA-4491474.71
Initiation of Nuclear Envelope ReformationR-HSA-29953839.28
Signaling by Rho GTPasesR-HSA-1943154.43
Negative regulation of FGFR3 signalingR-HSA-56547328.12
Cytokine Signaling in Immune systemR-HSA-12802153.74
SOS-mediated signallingR-HSA-1124125.15
MetabolismR-HSA-14307282.34
disassembly of the destruction complex and recruitment of AXIN to the membraneR-HSA-46412628.03
Signaling by ERBB4R-HSA-12363944.7
Assembly of the primary ciliumR-HSA-56178335.44
MAPK1/MAPK3 signalingR-HSA-56849965.11
Adaptive Immune SystemR-HSA-12802183.19
DARPP-32 eventsR-HSA-1800248.4
MAPK family signaling cascadesR-HSA-56830574.89
Signalling by NGFR-HSA-1665204.23
G1 PhaseR-HSA-692367.73
AXIN missense mutants destabilize the destruction complexR-HSA-54673409.18
Cyclin D associated events in G1R-HSA-692317.73
Platelet sensitization by LDLR-HSA-4321428.89
Costimulation by the CD28 familyR-HSA-3888416.56
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
RHO GTPases Activate ForminsR-HSA-56632206.01
Signaling by FGFRR-HSA-1902364.67
Loss of proteins required for interphase microtubule organization from the centrosomeR-HSA-3802847.03
Centrosome maturationR-HSA-3802876.68
SHC1 events in ERBB4 signalingR-HSA-12503475.15
Signaling by SCF-KITR-HSA-14335574.73
NCAM signaling for neurite out-growthR-HSA-3751654.9
S45 mutants of beta-catenin aren't phosphorylatedR-HSA-53587519.08
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
Resolution of Sister Chromatid CohesionR-HSA-25002576.18
Negative regulation of MAPK pathwayR-HSA-56752217.66
RHO GTPase EffectorsR-HSA-1952584.94
Signaling by GPCRR-HSA-3727902.68
Degradation of beta-catenin by the destruction complexR-HSA-1952536.64
truncated APC mutants destabilize the destruction complexR-HSA-48397449.18
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complexR-HSA-48397439.08
AMER1 mutants destabilize the destruction complexR-HSA-48397489.18
HemostasisR-HSA-1095823.98
Signal TransductionR-HSA-1625821.78
Nuclear Envelope ReassemblyR-HSA-29954109.28
Associated GO terms for Molecular function
GO termGO IDGO IC
hydrolase activityGO:00167871.9
protein heterodimerization activityGO:00469823.64
phosphatase activityGO:00167914.11
antigen bindingGO:00038235.02
protein phosphatase regulator activityGO:00198885.41
enzyme regulator activityGO:00302342.85
protein serine/threonine phosphatase activityGO:00047225.58
phosphoprotein phosphatase activityGO:00047214.55
hydrolase activity, acting on ester bondsGO:00167883.1
catalytic activityGO:00038241.05
bindingGO:00054880.18
protein bindingGO:00055150.46
phosphoric ester hydrolase activityGO:00425783.82
protein phosphatase type 2A regulator activityGO:00086016.69
protein dimerization activityGO:00469832.72
molecular function regulatorGO:00987722.51
phosphatase regulator activityGO:00192085.26