Gene table of PPP2R5D : protein phosphatase 2 regulatory subunit B'delta

Gene-disease associations table

Disease IDDisease nameSource of annotation with PPP2R5DOMIM linkNumber of associated genesgenes
PS156200MENTAL RETARDATION, AUTOSOMAL DOMINANTClinVar, OMIM, HUMSAVAR link to OMIM 44EHMT1, KANSL1, AHDC1, SOX11, CDH15, KIRREL3, EEF1A2, KAT6A, ZMYND11, ARID1A, KMT2C, PPP2R5D, DYNC1H1, GRIN1, CTCF, SETD5, AUTS2, PACS1, DPP6, MBD5, DEAF1, KIF1A, SYNGAP1, PURA, POGZ, EPB41L1, PPP2R1A, NR1I3, CTNNB1, ARID1B, MYT1L, CACNG2, COL4A3BP, SMARCB1, MEF2C, SMARCE1, SMARCA4, ZBTB18, ADNP, GATAD2B, SETBP1, GRIN2B, CHAMP1, DYRK1A

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Annotation of the gene PPP2R5D

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST
Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Oocyte meiosishsa041145.91
mRNA surveillance pathwayhsa030156.28
Dopaminergic synapsehsa047285.69
AMPK signaling pathwayhsa041525.8
Adrenergic signaling in cardiomyocyteshsa042615.44
PI3K-Akt signaling pathwayhsa041514.21
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Glucose metabolismR-HSA-703266.77
Toll Like Receptor 4 (TLR4) CascadeR-HSA-1660166.11
Cell CycleR-HSA-16401703.89
Developmental BiologyR-HSA-12667383.48
Signaling by VEGFR-HSA-1941384.66
FCERI mediated MAPK activationR-HSA-28717964.32
Toll Like Receptor 3 (TLR3) CascadeR-HSA-1681646.47
Beta-catenin phosphorylation cascadeR-HSA-1962998.89
Signaling by EGFRR-HSA-1779294.59
AXIN mutants destabilize the destruction complex, activating WNT signalingR-HSA-48397359.18
Platelet homeostasisR-HSA-4183466.68
Nuclear Events (kinase and transcription factor activation)R-HSA-1987258.4
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
Interleukin-2 signalingR-HSA-4519275.05
MAP kinase activation in TLR cascadeR-HSA-4502947.28
truncations of AMER1 destabilize the destruction complexR-HSA-54673489.18
Toll Like Receptor TLR1:TLR2 CascadeR-HSA-1681796.51
misspliced GSK3beta mutants stabilize beta-cateninR-HSA-53397169.08
S33 mutants of beta-catenin aren't phosphorylatedR-HSA-53587479.08
S37 mutants of beta-catenin aren't phosphorylatedR-HSA-53587499.08
Toll Like Receptor 5 (TLR5) CascadeR-HSA-1681766.73
DAP12 interactionsR-HSA-21721274.56
Downstream signaling of activated FGFR4R-HSA-56547164.71
Signaling by ERBB2R-HSA-12279864.66
VEGFR2 mediated cell proliferationR-HSA-52189215.07
Signaling by WNT in cancerR-HSA-47912757.89
ERK/MAPK targetsR-HSA-1987538.59
Immune SystemR-HSA-1682562.37
Frs2-mediated activationR-HSA-1709685.12
Downstream signal transductionR-HSA-1867634.65
RAF activationR-HSA-56730008.34
RAF/MAP kinase cascadeR-HSA-56730015.15
T41 mutants of beta-catenin aren't phosphorylatedR-HSA-53587529.08
MAPK targets/ Nuclear events mediated by MAP kinasesR-HSA-4502828.08
Toll Like Receptor 10 (TLR10) CascadeR-HSA-1681426.73
Mitotic Metaphase and AnaphaseR-HSA-25553965.45
Signalling to p38 via RIT and RINR-HSA-1877065.12
CTLA4 inhibitory signalingR-HSA-3895138.52
FRS-mediated FGFR2 signalingR-HSA-56547005.14
Cell Cycle, MitoticR-HSA-692784.16
FRS-mediated FGFR3 signalingR-HSA-56547065.14
MyD88-independent TLR3/TLR4 cascade R-HSA-1661666.47
Downstream signaling of activated FGFR3R-HSA-56547084.71
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Interleukin receptor SHC signalingR-HSA-9125265.09
Innate Immune SystemR-HSA-1682493.17
Integration of energy metabolismR-HSA-1636856.24
TCF dependent signaling in response to WNTR-HSA-2016815.36
Mitotic AnaphaseR-HSA-688825.46
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
Prolonged ERK activation eventsR-HSA-1698935.11
Signaling by WntR-HSA-1957214.79
Signaling by FGFR2R-HSA-56547384.68
PP2A-mediated dephosphorylation of key metabolic factorsR-HSA-16376710.18
SHC1 events in ERBB4 signalingR-HSA-12503475.15
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationR-HSA-9751386.72
MyD88 cascade initiated on plasma membraneR-HSA-9758716.73
ERKs are inactivatedR-HSA-2026709.4
Axon guidanceR-HSA-4224753.93
APC truncation mutants have impaired AXIN bindingR-HSA-54673379.18
Mitotic PrometaphaseR-HSA-688776.08
TRIF-mediated TLR3/TLR4 signaling R-HSA-9370616.47
Toll Like Receptor 2 (TLR2) CascadeR-HSA-1814386.51
Signaling by LeptinR-HSA-25865525.1
IGF1R signaling cascadeR-HSA-24289244.85
IRS-related events triggered by IGF1RR-HSA-24289284.85
M PhaseR-HSA-688864.87
IRS-mediated signallingR-HSA-1123994.87
Signaling by Insulin receptorR-HSA-747524.73
DiseaseR-HSA-16436853.33
Insulin receptor signalling cascadeR-HSA-747514.85
Downstream signaling of activated FGFR1R-HSA-56546874.71
Metabolism of carbohydratesR-HSA-713874.93
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
Toll-Like Receptors CascadesR-HSA-1688985.91
Toll Like Receptor TLR6:TLR2 CascadeR-HSA-1681886.56
Diseases of signal transductionR-HSA-56632024.89
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Toll Like Receptor 7/8 (TLR7/8) CascadeR-HSA-1681816.68
Signalling to RASR-HSA-1670445.08
GlycolysisR-HSA-701718.03
Downstream signaling of activated FGFR2R-HSA-56546964.71
SHC1 events in EGFR signalingR-HSA-1803365.15
FRS-mediated FGFR1 signalingR-HSA-56546935.14
Degradation of beta-catenin by the destruction complexR-HSA-1952536.64
SHC1 events in ERBB2 signalingR-HSA-12501965.15
Opioid SignallingR-HSA-1118856.64
ARMS-mediated activationR-HSA-1709845.12
GRB2 events in EGFR signalingR-HSA-1798125.15
MyD88 dependent cascade initiated on endosomeR-HSA-9751556.68
MyD88:Mal cascade initiated on plasma membraneR-HSA-1660586.56
Signaling by FGFR1R-HSA-56547364.69
Signaling by PDGFR-HSA-1867974.53
Activated TLR4 signallingR-HSA-1660546.27
Toll Like Receptor 9 (TLR9) CascadeR-HSA-1681386.62
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Separation of Sister ChromatidsR-HSA-24678135.55
Signaling by InterleukinsR-HSA-4491474.71
Signaling by Rho GTPasesR-HSA-1943154.43
Cytokine Signaling in Immune systemR-HSA-12802153.74
SOS-mediated signallingR-HSA-1124125.15
MetabolismR-HSA-14307282.34
disassembly of the destruction complex and recruitment of AXIN to the membraneR-HSA-46412628.03
Signaling by ERBB4R-HSA-12363944.7
MAPK1/MAPK3 signalingR-HSA-56849965.11
Adaptive Immune SystemR-HSA-12802183.19
DARPP-32 eventsR-HSA-1800248.4
MAPK family signaling cascadesR-HSA-56830574.89
Signalling by NGFR-HSA-1665204.23
AXIN missense mutants destabilize the destruction complexR-HSA-54673409.18
Platelet sensitization by LDLR-HSA-4321428.89
Costimulation by the CD28 familyR-HSA-3888416.56
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
RHO GTPases Activate ForminsR-HSA-56632206.01
Signaling by FGFRR-HSA-1902364.67
Signaling by SCF-KITR-HSA-14335574.73
NCAM signaling for neurite out-growthR-HSA-3751654.9
S45 mutants of beta-catenin aren't phosphorylatedR-HSA-53587519.08
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
Resolution of Sister Chromatid CohesionR-HSA-25002576.18
Negative regulation of MAPK pathwayR-HSA-56752217.66
RHO GTPase EffectorsR-HSA-1952584.94
FRS-mediated FGFR4 signalingR-HSA-56547125.14
Signaling by GPCRR-HSA-3727902.68
Signalling to ERKsR-HSA-1876875.04
truncated APC mutants destabilize the destruction complexR-HSA-48397449.18
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complexR-HSA-48397439.08
AMER1 mutants destabilize the destruction complexR-HSA-48397489.18
HemostasisR-HSA-1095823.98
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
hydrolase activityGO:00167871.9
phosphatase activityGO:00167914.11
protein phosphatase regulator activityGO:00198885.41
enzyme regulator activityGO:00302342.85
protein serine/threonine phosphatase activityGO:00047225.58
hydrolase activity, acting on ester bondsGO:00167883.1
phosphoric ester hydrolase activityGO:00425783.82
catalytic activityGO:00038241.05
phosphoprotein phosphatase activityGO:00047214.55
protein bindingGO:00055150.46
protein phosphatase type 2A regulator activityGO:00086016.69
molecular function regulatorGO:00987722.51
phosphatase regulator activityGO:00192085.26
bindingGO:00054880.18