| Disease ID | Disease name | Source of annotation with PRKACG | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS231200 | BLEEDING DISORDER, PLATELET-TYPE | ClinVar, OMIM, HUMSAVAR | link to OMIM | 21 | NBEAL2, ANO6, GP1BA, ITGA2, GFI1B, ITGA2B, PLAU, PRKACG, P2RY12, ACTN1, TBXAS1, P2RX1, GP6, CD36, SLFN14, ITGB3, GP9, GP1BB, RASGRP2, TBXA2R, MYH9 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Hedgehog signaling pathway | hsa04340 | 7.01 |
| Platelet activation | hsa04611 | 5.66 |
| Calcium signaling pathway | hsa04020 | 5.22 |
| Serotonergic synapse | hsa04726 | 5.84 |
| cAMP signaling pathway | hsa04024 | 5.05 |
| Long-term potentiation | hsa04720 | 6.64 |
| Retrograde endocannabinoid signaling | hsa04723 | 6.03 |
| Cholinergic synapse | hsa04725 | 5.88 |
| Taste transduction | hsa04742 | 6.99 |
| GABAergic synapse | hsa04727 | 6.24 |
| Olfactory transduction | hsa04740 | 4.13 |
| Dopaminergic synapse | hsa04728 | 5.69 |
| Dilated cardiomyopathy | hsa05414 | 6.08 |
| Oxytocin signaling pathway | hsa04921 | 5.4 |
| Vasopressin-regulated water reabsorption | hsa04962 | 7.18 |
| Endocrine and other factor-regulated calcium reabsorption | hsa04961 | 7.12 |
| Circadian entrainment | hsa04713 | 6.11 |
| Chemokine signaling pathway | hsa04062 | 5.19 |
| Amoebiasis | hsa05146 | 5.82 |
| Epstein-Barr virus infection | hsa05169 | 4.97 |
| Apoptosis | hsa04210 | 6.23 |
| HTLV-I infection | hsa05166 | 4.59 |
| Wnt signaling pathway | hsa04310 | 5.49 |
| Vascular smooth muscle contraction | hsa04270 | 5.74 |
| Gap junction | hsa04540 | 6.24 |
| Proteoglycans in cancer | hsa05205 | 5.02 |
| Estrogen signaling pathway | hsa04915 | 6.11 |
| Pathways in cancer | hsa05200 | 3.98 |
| Viral carcinogenesis | hsa05203 | 5.08 |
| GnRH signaling pathway | hsa04912 | 6.18 |
| Ovarian steroidogenesis | hsa04913 | 7.07 |
| Insulin signaling pathway | hsa04910 | 5.55 |
| Insulin secretion | hsa04911 | 6.18 |
| Inflammatory mediator regulation of TRP channels | hsa04750 | 6.07 |
| Oocyte meiosis | hsa04114 | 5.91 |
| Progesterone-mediated oocyte maturation | hsa04914 | 6.18 |
| MAPK signaling pathway | hsa04010 | 4.63 |
| Thyroid hormone synthesis | hsa04918 | 6.56 |
| Thyroid hormone signaling pathway | hsa04919 | 5.82 |
| Salivary secretion | hsa04970 | 6.23 |
| Gastric acid secretion | hsa04971 | 6.48 |
| Vibrio cholerae infection | hsa05110 | 6.86 |
| Ras signaling pathway | hsa04014 | 4.9 |
| Bile secretion | hsa04976 | 6.56 |
| Prion diseases | hsa05020 | 7.48 |
| Morphine addiction | hsa05032 | 6.15 |
| Cocaine addiction | hsa05030 | 7.07 |
| Amphetamine addiction | hsa05031 | 6.62 |
| Melanogenesis | hsa04916 | 5.97 |
| Adrenergic signaling in cardiomyocytes | hsa04261 | 5.44 |
| Parkinson's disease | hsa05012 | 5.59 |
| Glutamatergic synapse | hsa04724 | 5.84 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Phospholipase C-mediated cascade; FGFR2 | R-HSA-5654221 | 7.37 |
| Signalling by NGF | R-HSA-166520 | 4.23 |
| PLCG1 events in ERBB2 signaling | R-HSA-1251932 | 7.85 |
| DAG and IP3 signaling | R-HSA-1489509 | 7.98 |
| Phospholipase C-mediated cascade; FGFR3 | R-HSA-5654227 | 7.52 |
| Ca-dependent events | R-HSA-111996 | 8.18 |
| CREB phosphorylation through the activation of Adenylate Cyclase | R-HSA-442720 | 10.18 |
| Signaling by Hedgehog | R-HSA-5358351 | 5.79 |
| Immune System | R-HSA-168256 | 2.37 |
| Transmembrane transport of small molecules | R-HSA-382551 | 3.79 |
| Metabolism | R-HSA-1430728 | 2.34 |
| Downstream signal transduction | R-HSA-186763 | 4.65 |
| Degradation of GLI1 by the proteasome | R-HSA-5610780 | 7.1 |
| Post NMDA receptor activation events | R-HSA-438064 | 7.85 |
| Factors involved in megakaryocyte development and platelet production | R-HSA-983231 | 5.88 |
| Vasopressin regulates renal water homeostasis via Aquaporins | R-HSA-432040 | 7.56 |
| Adaptive Immune System | R-HSA-1280218 | 3.19 |
| Glucose metabolism | R-HSA-70326 | 6.77 |
| Calmodulin induced events | R-HSA-111933 | 8.28 |
| Degradation of GLI2 by the proteasome | R-HSA-5610783 | 7.1 |
| PKA-mediated phosphorylation of CREB | R-HSA-111931 | 8.89 |
| DARPP-32 events | R-HSA-180024 | 8.4 |
| Downstream signaling of activated FGFR1 | R-HSA-5654687 | 4.71 |
| Metabolism of carbohydrates | R-HSA-71387 | 4.93 |
| PKA activation | R-HSA-163615 | 8.98 |
| GLI3 is processed to GLI3R by the proteasome | R-HSA-5610785 | 7.1 |
| Signaling by VEGF | R-HSA-194138 | 4.66 |
| PKA activation in glucagon signalling | R-HSA-164378 | 8.89 |
| Rap1 signalling | R-HSA-392517 | 8.98 |
| G-protein mediated events | R-HSA-112040 | 7.49 |
| PKA-mediated phosphorylation of key metabolic factors | R-HSA-163358 | 10.66 |
| Phospholipase C-mediated cascade; FGFR4 | R-HSA-5654228 | 7.46 |
| Neuronal System | R-HSA-112316 | 4.82 |
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | R-HSA-112314 | 5.85 |
| Glucagon signaling in metabolic regulation | R-HSA-163359 | 7.94 |
| Signaling by FGFR4 | R-HSA-5654743 | 4.69 |
| Signaling by FGFR3 | R-HSA-5654741 | 4.69 |
| C-type lectin receptors (CLRs) | R-HSA-5621481 | 6.06 |
| VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 4.7 |
| Metabolism of lipids and lipoproteins | R-HSA-556833 | 3.79 |
| Signaling by FGFR | R-HSA-190236 | 4.67 |
| Downstream signaling of activated FGFR3 | R-HSA-5654708 | 4.71 |
| MAPK6/MAPK4 signaling | R-HSA-5687128 | 6.54 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis | R-HSA-163560 | 8.66 |
| Aquaporin-mediated transport | R-HSA-445717 | 7.31 |
| Integration of energy metabolism | R-HSA-163685 | 6.24 |
| Signaling by ERBB2 | R-HSA-1227986 | 4.66 |
| EGFR interacts with phospholipase C-gamma | R-HSA-212718 | 7.89 |
| DAP12 signaling | R-HSA-2424491 | 4.64 |
| Lipid digestion, mobilization, and transport | R-HSA-73923 | 7.2 |
| Hedgehog 'off' state | R-HSA-5610787 | 6.19 |
| Activation of NMDA receptor upon glutamate binding and postsynaptic events | R-HSA-442755 | 7.7 |
| Downstream signaling of activated FGFR2 | R-HSA-5654696 | 4.71 |
| Signaling by EGFR | R-HSA-177929 | 4.59 |
| NGF signalling via TRKA from the plasma membrane | R-HSA-187037 | 4.51 |
| PLC beta mediated events | R-HSA-112043 | 7.52 |
| Transmission across Chemical Synapses | R-HSA-112315 | 5.28 |
| Regulation of insulin secretion | R-HSA-422356 | 6.66 |
| PLC-gamma1 signalling | R-HSA-167021 | 7.89 |
| Signaling by GPCR | R-HSA-372790 | 2.68 |
| Signaling by FGFR2 | R-HSA-5654738 | 4.68 |
| Signaling by FGFR1 | R-HSA-5654736 | 4.69 |
| Opioid Signalling | R-HSA-111885 | 6.64 |
| MAPK family signaling cascades | R-HSA-5683057 | 4.89 |
| CD209 (DC-SIGN) signaling | R-HSA-5621575 | 8.59 |
| Phospholipase C-mediated cascade: FGFR1 | R-HSA-5654219 | 7.43 |
| CaM pathway | R-HSA-111997 | 8.28 |
| DAP12 interactions | R-HSA-2172127 | 4.56 |
| Downstream signaling of activated FGFR4 | R-HSA-5654716 | 4.71 |
| Signaling by PDGF | R-HSA-186797 | 4.53 |
| Gluconeogenesis | R-HSA-70263 | 8.03 |
| Hemostasis | R-HSA-109582 | 3.98 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | R-HSA-381676 | 7.59 |
| GO term | GO ID | GO IC |
|---|---|---|
| purine ribonucleoside triphosphate binding | GO:0035639 | 2.22 |
| binding | GO:0005488 | 0.18 |
| cAMP-dependent protein kinase activity | GO:0004691 | 7.79 |
| cyclic nucleotide-dependent protein kinase activity | GO:0004690 | 7.54 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| nucleoside phosphate binding | GO:1901265 | 1.96 |
| nucleoside binding | GO:0001882 | 2.21 |
| nucleotide binding | GO:0000166 | 1.96 |
| protein serine/threonine kinase activity | GO:0004674 | 3.64 |
| transferase activity | GO:0016740 | 1.95 |
| purine nucleoside binding | GO:0001883 | 2.22 |
| ribonucleoside binding | GO:0032549 | 2.22 |
| purine nucleotide binding | GO:0017076 | 2.19 |
| protein kinase activity | GO:0004672 | 3.27 |
| ATP binding | GO:0005524 | 2.43 |
| kinase activity | GO:0016301 | 2.93 |
| small molecule binding | GO:0036094 | 1.89 |
| catalytic activity | GO:0003824 | 1.05 |
| adenyl nucleotide binding | GO:0030554 | 2.4 |
| phosphotransferase activity, alcohol group as acceptor | GO:0016773 | 3.08 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| carbohydrate derivative binding | GO:0097367 | 2.03 |
| adenyl ribonucleotide binding | GO:0032559 | 2.41 |
| transferase activity, transferring phosphorus-containing groups | GO:0016772 | 2.77 |
| purine ribonucleotide binding | GO:0032555 | 2.2 |
| purine ribonucleoside binding | GO:0032550 | 2.22 |
| ribonucleotide binding | GO:0032553 | 2.19 |