Gene table of PRKCD : protein kinase C delta

Gene-disease associations table

Disease ID	Disease name	Source of annotation with PRKCD	OMIM link	Number of associated genes	genes
615559	AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE III	ClinVar, OMIM	link to OMIM	1	PRKCD

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Annotation of the gene PRKCD

Associated genes in ENSEMBL

ENSG00000163932

Associated proteins - SwissProt Accession ID

Q05655

Associated PDB IDs

Cytogenetic Band

3p21.1

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
GnRH signaling pathway	hsa04912	6.18
Type II diabetes mellitus	hsa04930	7.12
Tight junction	hsa04530	5.53
Neurotrophin signaling pathway	hsa04722	5.78
Fc epsilon RI signaling pathway	hsa04664	6.6
Fc gamma R-mediated phagocytosis	hsa04666	6.21
Estrogen signaling pathway	hsa04915	6.11
Inflammatory mediator regulation of TRP channels	hsa04750	6.07
Chemokine signaling pathway	hsa04062	5.19
Vascular smooth muscle contraction	hsa04270	5.74

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	7.37
PLCG1 events in ERBB2 signaling	R-HSA-1251932	7.85
DAG and IP3 signaling	R-HSA-1489509	7.98
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	7.52
Role of phospholipids in phagocytosis	R-HSA-2029485	5.47
Ca-dependent events	R-HSA-111996	8.18
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	7.46
G alpha (z) signalling events	R-HSA-418597	7.46
Immune System	R-HSA-168256	2.37
Apoptotic execution phase	R-HSA-75153	7.28
Programmed Cell Death	R-HSA-5357801	5.65
Downstream signal transduction	R-HSA-186763	4.65
Effects of PIP2 hydrolysis	R-HSA-114508	8.34
Calmodulin induced events	R-HSA-111933	8.28
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71
CaM pathway	R-HSA-111997	8.28
Signalling by NGF	R-HSA-166520	4.23
Apoptotic cleavage of cellular proteins	R-HSA-111465	7.73
Gene Expression	R-HSA-74160	2.72
Platelet activation, signaling and aggregation	R-HSA-76002	5.15
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26
Signaling by EGFR	R-HSA-177929	4.59
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	7.43
Interferon gamma signaling	R-HSA-877300	5.67
Interferon Signaling	R-HSA-913531	4.95
Signaling by GPCR	R-HSA-372790	2.68
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71
Signaling by FGFR4	R-HSA-5654743	4.69
Signaling by FGFR3	R-HSA-5654741	4.69
C-type lectin receptors (CLRs)	R-HSA-5621481	6.06
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	5.07
Signaling by FGFR	R-HSA-190236	4.67
GPCR downstream signaling	R-HSA-388396	3.07
Signaling by ERBB2	R-HSA-1227986	4.66
Innate Immune System	R-HSA-168249	3.17
Signaling by PDGF	R-HSA-186797	4.53
CLEC7A (Dectin-1) signaling	R-HSA-5607764	6.38
DAP12 signaling	R-HSA-2424491	4.64
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71
Regulation of mRNA stability by proteins that bind AU-rich elements	R-HSA-450531	6.56
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51
PLC-gamma1 signalling	R-HSA-167021	7.89
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.89
PLC beta mediated events	R-HSA-112043	7.52
G-protein mediated events	R-HSA-112040	7.49
Signaling by FGFR2	R-HSA-5654738	4.68
Signaling by FGFR1	R-HSA-5654736	4.69
Opioid Signalling	R-HSA-111885	6.64
G alpha (q) signalling events	R-HSA-416476	5.42
Signaling by VEGF	R-HSA-194138	4.66
DAP12 interactions	R-HSA-2172127	4.56
Apoptosis	R-HSA-109581	5.68
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71
HuR stabilizes mRNA	R-HSA-450520	9.98
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07
Hemostasis	R-HSA-109582	3.98
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
enzyme binding	GO:0019899	2.27
calcium-independent protein kinase C activity	GO:0004699	8.64
binding	GO:0005488	0.18
molecular function regulator	GO:0098772	2.51
protein kinase C activity	GO:0004697	6.97
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
insulin receptor substrate binding	GO:0043560	7.25
ion binding	GO:0043167	1.36
protein serine/threonine kinase activity	GO:0004674	3.64
transferase activity	GO:0016740	1.95
non-membrane spanning protein tyrosine kinase activity	GO:0004715	5.91
purine nucleoside binding	GO:0001883	2.22
protein kinase activity	GO:0004672	3.27
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
ATP binding	GO:0005524	2.43
protein tyrosine kinase activity	GO:0004713	4.54
kinase activity	GO:0016301	2.93
nucleotide binding	GO:0000166	1.96
enzyme regulator activity	GO:0030234	2.85
ribonucleoside binding	GO:0032549	2.22
protein kinase binding	GO:0019901	3.44
kinase binding	GO:0019900	3.32
small molecule binding	GO:0036094	1.89
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
catalytic activity	GO:0003824	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
enzyme activator activity	GO:0008047	3.56