Gene table of PRKDC : protein kinase, DNA-activated, catalytic polypeptide

Gene-disease associations table

Disease ID	Disease name	Source of annotation with PRKDC	OMIM link	Number of associated genes	genes
615966	IMMUNODEFICIENCY 26 WITH OR WITHOUT NEUROLOGIC ABNORMALITIES	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	PRKDC

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Cell cycle	hsa04110	5.68
Non-homologous end-joining	hsa03450	8.96

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
IRF3-mediated induction of type I IFN	R-HSA-3270619	9.28
Innate Immune System	R-HSA-168249	3.17
Processing of DNA ends prior to end rejoining	R-HSA-75924	10.66
Immune System	R-HSA-168256	2.37
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	6.94
Nonhomologous End-Joining (NHEJ)	R-HSA-73889	10.18
DNA Repair	R-HSA-73894	5.8
Double-Strand Break Repair	R-HSA-73890	8.46
STING mediated induction of host immune responses	R-HSA-1834941	8.98

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
enzyme binding	GO:0019899	2.27
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
transferase activity	GO:0016740	1.95
nucleotide binding	GO:0000166	1.96
protein serine/threonine kinase activity	GO:0004674	3.64
DNA-dependent protein kinase activity	GO:0004677	8.64
nucleoside phosphate binding	GO:1901265	1.96
protein kinase activity	GO:0004672	3.27
purine nucleotide binding	GO:0017076	2.19
double-stranded DNA binding	GO:0003690	3.09
transcription factor binding	GO:0008134	3.46
ATP binding	GO:0005524	2.43
kinase activity	GO:0016301	2.93
poly(A) RNA binding	GO:0044822	2.69
ribonucleoside binding	GO:0032549	2.22
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
adenyl ribonucleotide binding	GO:0032559	2.41
RNA binding	GO:0003723	2.36
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19