Gene table of PRKG1 : protein kinase, cGMP-dependent, type I

Gene-disease associations table

Disease ID	Disease name	Source of annotation with PRKG1	OMIM link	Number of associated genes	genes
PS607086	AORTIC ANEURYSM, FAMILIAL THORACIC	ClinVar, OMIM, HUMSAVAR	link to OMIM	7	TGFBR2, ACTA2, TGFBR1, MYH11, MYLK, PRKG1, MFAP5

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Salivary secretion	hsa04970	6.23
Platelet activation	hsa04611	5.66
Gap junction	hsa04540	6.24
cGMP-PKG signaling pathway	hsa04022	5.32
Olfactory transduction	hsa04740	4.13
Circadian entrainment	hsa04713	6.11
Long-term depression	hsa04730	6.74
Vascular smooth muscle contraction	hsa04270	5.74

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Signaling by Wnt	R-HSA-195721	4.79
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	8.34
beta-catenin independent WNT signaling	R-HSA-3858494	5.83
cGMP effects	R-HSA-418457	8.81
Immune System	R-HSA-168256	2.37
Hemostasis	R-HSA-109582	3.98
Ca2+ pathway	R-HSA-4086398	7.1
Platelet homeostasis	R-HSA-418346	6.68
Rap1 signalling	R-HSA-392517	8.98
Adaptive Immune System	R-HSA-1280218	3.19
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
binding	GO:0005488	0.18
cGMP-dependent protein kinase activity	GO:0004692	9.05
molecular function regulator	GO:0098772	2.51
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
cyclic nucleotide-dependent protein kinase activity	GO:0004690	7.54
guanyl ribonucleotide binding	GO:0032561	3.73
carbohydrate derivative binding	GO:0097367	2.03
ribonucleoside binding	GO:0032549	2.22
nucleotide binding	GO:0000166	1.96
protein serine/threonine kinase activity	GO:0004674	3.64
transferase activity	GO:0016740	1.95
purine nucleoside binding	GO:0001883	2.22
protein kinase activity	GO:0004672	3.27
channel regulator activity	GO:0016247	4.88
purine nucleotide binding	GO:0017076	2.19
ATP binding	GO:0005524	2.43
kinase activity	GO:0016301	2.93
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
cGMP binding	GO:0030553	6.97
cyclic nucleotide binding	GO:0030551	6.13
adenyl nucleotide binding	GO:0030554	2.4
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
organic cyclic compound binding	GO:0097159	1.05
guanyl nucleotide binding	GO:0019001	3.73
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
calcium channel regulator activity	GO:0005246	6.15
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19