Gene table of PSMA6 : proteasome subunit alpha 6

Gene-disease associations table

Disease IDDisease nameSource of annotation with PSMA6OMIM linkNumber of associated genesgenes
608446MYOCARDIAL INFARCTION, SUSCEPTIBILITY TOOMIM link to OMIM 14LTA, ACE, ITGB3, OLR1, GCLC, ESR1, GCLM, LGALS2, MIAT, LRP8, F7, PSMA6, F13A1, TNFSF4

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Annotation of the gene PSMA6

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST
Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Proteasomehsa030507.21
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Interleukin-2 signalingR-HSA-4519275.05
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
Cell CycleR-HSA-16401703.89
Developmental BiologyR-HSA-12667383.48
Switching of origins to a post-replicative stateR-HSA-690526.85
Metabolism of amino acids and derivativesR-HSA-712915.4
Signaling by VEGFR-HSA-1941384.66
FCERI mediated MAPK activationR-HSA-28717964.32
HIV InfectionR-HSA-1629065.22
Signaling by EGFRR-HSA-1779294.59
Cell Cycle CheckpointsR-HSA-696205.64
Orc1 removal from chromatinR-HSA-689496.85
p53-Dependent G1/S DNA damage checkpointR-HSA-695807.15
Regulation of mRNA stability by proteins that bind AU-rich elementsR-HSA-4505316.56
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
Assembly of the pre-replicative complexR-HSA-688676.92
Regulation of APC/C activators between G1/S and early anaphaseR-HSA-1764086.72
APC/C:Cdc20 mediated degradation of mitotic proteinsR-HSA-1764096.81
beta-catenin independent WNT signalingR-HSA-38584945.83
Regulation of activated PAK-2p34 by proteasome mediated degradationR-HSA-2117337.37
Class I MHC mediated antigen processing & presentationR-HSA-9831694.65
Hedgehog ligand biogenesisR-HSA-53583466.98
Downstream signaling of activated FGFR3R-HSA-56547084.71
Autodegradation of the E3 ubiquitin ligase COP1R-HSA-3494257.31
G1/S TransitionR-HSA-692066.21
TCF dependent signaling in response to WNTR-HSA-2016815.36
Cyclin E associated events during G1/S transition R-HSA-692026.96
SCF-beta-TrCP mediated degradation of Emi1R-HSA-1741137.23
G1/S DNA Damage CheckpointsR-HSA-696157.08
FRS-mediated FGFR4 signalingR-HSA-56547125.14
p53-Independent DNA Damage ResponseR-HSA-696107.28
p53-Independent G1/S DNA damage checkpointR-HSA-696137.28
Downstream signaling of activated FGFR4R-HSA-56547164.71
Signaling by ERBB2R-HSA-12279864.66
VEGFR2 mediated cell proliferationR-HSA-52189215.07
FCERI mediated NF-kB activationR-HSA-28718375.11
Immune SystemR-HSA-1682562.37
Frs2-mediated activationR-HSA-1709685.12
CDK-mediated phosphorylation and removal of Cdc6R-HSA-690177.34
Regulation of ornithine decarboxylase (ODC)R-HSA-3505627.34
Downstream signal transductionR-HSA-1867634.65
Hh mutants that don't undergo autocatalytic processing are degraded by ERADR-HSA-53627687.2
Signaling by HedgehogR-HSA-53583515.79
Vpu mediated degradation of CD4R-HSA-1805347.31
SCF(Skp2)-mediated degradation of p27/p21R-HSA-1875777.18
Mitotic Metaphase and AnaphaseR-HSA-25553965.45
Signalling to p38 via RIT and RINR-HSA-1877065.12
Ubiquitin Mediated Degradation of Phosphorylated Cdc25AR-HSA-696017.28
p53-Dependent G1 DNA Damage ResponseR-HSA-695637.15
FRS-mediated FGFR2 signalingR-HSA-56547005.14
Cell Cycle, MitoticR-HSA-692784.16
FRS-mediated FGFR3 signalingR-HSA-56547065.14
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointR-HSA-1794196.85
Activation of NF-kappaB in B cellsR-HSA-11690916.94
Mitotic G1-G1/S phasesR-HSA-4532795.91
Interleukin receptor SHC signalingR-HSA-9125265.09
Host Interactions of HIV factorsR-HSA-1629095.99
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Ubiquitin-dependent degradation of Cyclin DR-HSA-758157.34
Innate Immune SystemR-HSA-1682493.17
Vif-mediated degradation of APOBEC3GR-HSA-1805857.25
Dectin-1 mediated noncanonical NF-kB signalingR-HSA-56077617.1
CLEC7A (Dectin-1) signalingR-HSA-56077646.38
Mitotic AnaphaseR-HSA-688825.46
SOS-mediated signallingR-HSA-1124125.15
Regulation of mitotic cell cycleR-HSA-4532766.61
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
Prolonged ERK activation eventsR-HSA-1698935.11
Signaling by WntR-HSA-1957214.79
Signaling by FGFR2R-HSA-56547384.68
GRB2 events in EGFR signalingR-HSA-1798125.15
Signaling by FGFR1R-HSA-56547364.69
DNA ReplicationR-HSA-693066.25
DAP12 interactionsR-HSA-21721274.56
Removal of licensing factors from originsR-HSA-693006.81
Axon guidanceR-HSA-4224753.93
M/G1 TransitionR-HSA-688746.62
Signaling by LeptinR-HSA-25865525.1
Programmed Cell DeathR-HSA-53578015.65
IGF1R signaling cascadeR-HSA-24289244.85
IRS-related events triggered by IGF1RR-HSA-24289284.85
M PhaseR-HSA-688864.87
IRS-mediated signallingR-HSA-1123994.87
Signaling by Insulin receptorR-HSA-747524.73
DiseaseR-HSA-16436853.33
Insulin receptor signalling cascadeR-HSA-747514.85
Cross-presentation of soluble exogenous antigens (endosomes)R-HSA-12369787.37
Downstream signaling of activated FGFR1R-HSA-56546874.71
Gene ExpressionR-HSA-741602.72
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
Antigen processing-Cross presentationR-HSA-12369755.88
ER-Phagosome pathwayR-HSA-12369746.08
Stabilization of p53R-HSA-695417.28
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
Infectious diseaseR-HSA-56632054.47
AUF1 (hnRNP D0) destabilizes mRNAR-HSA-4504087.23
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Signalling to RASR-HSA-1670445.08
Downstream signaling of activated FGFR2R-HSA-56546964.71
SHC1 events in EGFR signalingR-HSA-1803365.15
DNA Replication Pre-InitiationR-HSA-690026.62
FRS-mediated FGFR1 signalingR-HSA-56546935.14
APC/C:Cdc20 mediated degradation of SecurinR-HSA-1741546.98
Cyclin A:Cdk2-associated events at S phase entryR-HSA-696566.94
SHC1 events in ERBB2 signalingR-HSA-12501965.15
PCP/CE pathwayR-HSA-40864006.47
ARMS-mediated activationR-HSA-1709845.12
S PhaseR-HSA-692426.02
Cdc20:Phospho-APC/C mediated degradation of Cyclin AR-HSA-1741846.87
Hedgehog 'on' stateR-HSA-56326846.62
Signalling to ERKsR-HSA-1876875.04
Signaling by PDGFR-HSA-1867974.53
MAPK family signaling cascadesR-HSA-56830574.89
C-type lectin receptors (CLRs)R-HSA-56214816.06
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Asymmetric localization of PCP proteinsR-HSA-46088707.01
Separation of Sister ChromatidsR-HSA-24678135.55
Signaling by InterleukinsR-HSA-4491474.71
Cytokine Signaling in Immune systemR-HSA-12802153.74
NIK--noncanonical NF-kB signalingR-HSA-56765907.12
MetabolismR-HSA-14307282.34
Degradation of GLI1 by the proteasomeR-HSA-56107807.1
Signaling by ERBB4R-HSA-12363944.7
MAPK1/MAPK3 signalingR-HSA-56849965.11
Adaptive Immune SystemR-HSA-12802183.19
APC/C-mediated degradation of cell cycle proteinsR-HSA-1741436.61
Degradation of GLI2 by the proteasomeR-HSA-56107837.1
TNFR2 non-canonical NF-kB pathwayR-HSA-56685416.4
Hedgehog 'off' stateR-HSA-56107876.19
Signalling by NGFR-HSA-1665204.23
GLI3 is processed to GLI3R by the proteasomeR-HSA-56107857.1
Diseases of signal transductionR-HSA-56632024.89
Hh mutants abrogate ligand secretionR-HSA-53873907.2
Regulation of DNA replicationR-HSA-693046.75
CDT1 association with the CDC6:ORC:origin complexR-HSA-688277.12
RAF/MAP kinase cascadeR-HSA-56730015.15
Signaling by FGFR4R-HSA-56547434.69
Synthesis of DNAR-HSA-692396.37
Signaling by FGFR3R-HSA-56547414.69
Signaling by FGFRR-HSA-1902364.67
Regulation of ApoptosisR-HSA-1699117.34
MAPK6/MAPK4 signalingR-HSA-56871286.54
SHC1 events in ERBB4 signalingR-HSA-12503475.15
Signaling by SCF-KITR-HSA-14335574.73
degradation of AXINR-HSA-46412577.23
NCAM signaling for neurite out-growthR-HSA-3751654.9
DAP12 signalingR-HSA-24244914.64
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1R-HSA-1741786.87
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
degradation of DVLR-HSA-46412587.18
Regulation of RAS by GAPsR-HSA-56584426.92
Signaling by GPCRR-HSA-3727902.68
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsR-HSA-1768146.79
Degradation of beta-catenin by the destruction complexR-HSA-1952536.64
Autodegradation of Cdh1 by Cdh1:APC/CR-HSA-1740847.08
Antigen processing: Ubiquitination & Proteasome degradationR-HSA-9831685.19
Signal TransductionR-HSA-1625821.78
Ubiquitin-dependent degradation of Cyclin D1R-HSA-692297.34
ApoptosisR-HSA-1095815.68
Associated GO terms for Molecular function
GO termGO IDGO IC
hydrolase activityGO:00167871.9
endopeptidase activityGO:00041753.63
protein bindingGO:00055150.46
purine ribonucleoside triphosphate bindingGO:00356392.22
organic cyclic compound bindingGO:00971591.05
transcription factor bindingGO:00081343.46
NF-kappaB bindingGO:00510596.34
threonine-type endopeptidase activityGO:00042986.6
catalytic activityGO:00038241.05
threonine-type peptidase activityGO:00700036.6
peptidase activity, acting on L-amino acid peptidesGO:00700113.26
bindingGO:00054880.18
nucleic acid bindingGO:00036761.44
peptidase activityGO:00082333.23
heterocyclic compound bindingGO:19013631.06
nucleoside phosphate bindingGO:19012651.96
RNA bindingGO:00037232.36