| Disease ID | Disease name | Source of annotation with PTPN1 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 125853 | DIABETES MELLITUS, NONINSULIN-DEPENDENT | OMIM | link to OMIM | 33 | SLC2A2, HNF4A, TCF7L2, SLC30A8, GPD2, PAX4, PTPN1, SLC2A4, ABCC8, HMGA1, LIPC, NEUROD1, CDKAL1, WFS1, PPARG, RETN, AKT2, IRS2, IL6, IRS1, GCGR, CAPN10, IGF2BP2, INSR, PDX1, MTNR1B, GCK, HNF1B, HNF1A, MAPK8IP1, ENPP1, PPP1R3A, KCNJ11 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Insulin signaling pathway | hsa04910 | 5.55 |
| Adherens junction | hsa04520 | 6.26 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Platelet Aggregation (Plug Formation) | R-HSA-76009 | 7.77 |
| Growth hormone receptor signaling | R-HSA-982772 | 8.4 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 5.15 |
| Immune System | R-HSA-168256 | 2.37 |
| Integrin alphaIIb beta3 signaling | R-HSA-354192 | 8.23 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 3.74 |
| Regulation of IFNG signaling | R-HSA-877312 | 9.18 |
| Regulation of IFNA signaling | R-HSA-912694 | 8.34 |
| Interferon gamma signaling | R-HSA-877300 | 5.67 |
| Interferon alpha/beta signaling | R-HSA-909733 | 6.04 |
| Interferon Signaling | R-HSA-913531 | 4.95 |
| Hemostasis | R-HSA-109582 | 3.98 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| phosphatase activity | GO:0016791 | 4.11 |
| enzyme binding | GO:0019899 | 2.27 |
| phosphoric ester hydrolase activity | GO:0042578 | 3.82 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| zinc ion binding | GO:0008270 | 2.66 |
| nucleic acid binding | GO:0003676 | 1.44 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| cation binding | GO:0043169 | 1.4 |
| transition metal ion binding | GO:0046914 | 2.48 |
| receptor tyrosine kinase binding | GO:0030971 | 5.77 |
| ion binding | GO:0043167 | 1.36 |
| protein complex binding | GO:0032403 | 3.09 |
| metal ion binding | GO:0046872 | 1.41 |
| protein tyrosine kinase binding | GO:1990782 | 5.7 |
| hydrolase activity | GO:0016787 | 1.9 |
| poly(A) RNA binding | GO:0044822 | 2.69 |
| insulin receptor binding | GO:0005158 | 6.27 |
| hydrolase activity, acting on ester bonds | GO:0016788 | 3.1 |
| protein kinase binding | GO:0019901 | 3.44 |
| kinase binding | GO:0019900 | 3.32 |
| protein phosphatase binding | GO:0019903 | 4.93 |
| phosphatase binding | GO:0019902 | 4.63 |
| protein phosphatase 2A binding | GO:0051721 | 6.41 |
| catalytic activity | GO:0003824 | 1.05 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| protein tyrosine phosphatase activity | GO:0004725 | 5.09 |
| phosphoprotein phosphatase activity | GO:0004721 | 4.55 |
| RNA binding | GO:0003723 | 2.36 |
| protein binding | GO:0005515 | 0.46 |
| receptor binding | GO:0005102 | 2.43 |
| ephrin receptor binding | GO:0046875 | 6.56 |
| binding | GO:0005488 | 0.18 |