Gene table of PTPN11 : protein tyrosine phosphatase, non-receptor type 11

Gene-disease associations table

Disease IDDisease nameSource of annotation with PTPN11OMIM linkNumber of associated genesgenes
PS151100LEOPARD SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 3RAF1, BRAF, PTPN11
156250METACHONDROMATOSISClinVar, OMIM link to OMIM 1PTPN11
PS163950NOONAN SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 9LZTR1, BRAF, RIT1, NRAS, KRAS, SOS2, PTPN11, SOS1, RAF1
607785JUVENILE MYELOMONOCYTIC LEUKEMIAClinVar, OMIM, HUMSAVAR link to OMIM 8MLLT11, NF1, ARHGAP26, KRAS, SETBP1, PTPN11, CBL, NRAS

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Annotation of the gene PTPN11

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST
Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Epithelial cell signaling in Helicobacter pylori infectionhsa051206.58
Proteoglycans in cancerhsa052055.02
Natural killer cell mediated cytotoxicityhsa046505.53
Renal cell carcinomahsa052116.6
Jak-STAT signaling pathwayhsa046305.44
Ras signaling pathwayhsa040144.9
Leukocyte transendothelial migrationhsa046705.74
Herpes simplex infectionhsa051685.08
Chronic myeloid leukemiahsa052206.48
Neurotrophin signaling pathwayhsa047225.78
Adipocytokine signaling pathwayhsa049206.6
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
PD-1 signalingR-HSA-3899487.62
GPVI-mediated activation cascadeR-HSA-1146047.18
Toll Like Receptor 4 (TLR4) CascadeR-HSA-1660166.11
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
Cell-Cell communicationR-HSA-15009315.87
Regulation of IFNA signalingR-HSA-9126948.34
GAB1 signalosomeR-HSA-1802926.31
Developmental BiologyR-HSA-12667383.48
Toll Like Receptor 3 (TLR3) CascadeR-HSA-1681646.47
IRS-mediated signallingR-HSA-1123994.87
Platelet homeostasisR-HSA-4183466.68
Signal regulatory protein (SIRP) family interactionsR-HSA-3911608.98
RAF-independent MAPK1/3 activationR-HSA-1124098.46
Spry regulation of FGF signalingR-HSA-12955969.18
Interferon SignalingR-HSA-9135314.95
Signaling by EGFRR-HSA-1779294.59
Nuclear signaling by ERBB4R-HSA-12519857.7
Prolactin receptor signalingR-HSA-11705469.08
MAPK1 (ERK2) activationR-HSA-1124119.81
PI-3K cascade:FGFR3R-HSA-56547106.37
Regulation of IFNG signalingR-HSA-8773129.18
FRS-mediated FGFR4 signalingR-HSA-56547125.14
Tie2 SignalingR-HSA-2109938.81
PECAM1 interactionsR-HSA-2109909.4
Signaling by ERBB2R-HSA-12279864.66
Netrin mediated repulsion signalsR-HSA-4188869.66
PI3K/AKT activationR-HSA-1982036.32
Immune SystemR-HSA-1682562.37
PI3K events in ERBB2 signalingR-HSA-19636426.37
Downstream signal transductionR-HSA-1867634.65
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.95
CTLA4 inhibitory signalingR-HSA-3895138.52
FRS-mediated FGFR2 signalingR-HSA-56547005.14
Interferon gamma signalingR-HSA-8773005.67
FRS-mediated FGFR3 signalingR-HSA-56547065.14
MyD88-independent TLR3/TLR4 cascade R-HSA-1661666.47
Downstream signaling of activated FGFR3R-HSA-56547084.71
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Downstream signaling of activated FGFR4R-HSA-56547164.71
Innate Immune SystemR-HSA-1682493.17
SHC-mediated cascade:FGFR4R-HSA-56547198.46
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
Signaling by FGFR2R-HSA-56547384.68
Signaling by FGFR1R-HSA-56547364.69
Negative regulation of FGFR4 signalingR-HSA-56547338.03
Negative regulation of FGFR3 signalingR-HSA-56547328.12
PI3K CascadeR-HSA-1097046.68
DAP12 interactionsR-HSA-21721274.56
Interferon alpha/beta signalingR-HSA-9097336.04
Axon guidanceR-HSA-4224753.93
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonR-HSA-9369648.81
TRIF-mediated TLR3/TLR4 signaling R-HSA-9370616.47
Signaling by LeptinR-HSA-25865525.1
Constitutive Signaling by Aberrant PI3K in CancerR-HSA-22195307.05
IGF1R signaling cascadeR-HSA-24289244.85
IRS-related events triggered by IGF1RR-HSA-24289284.85
Signaling by Insulin receptorR-HSA-747524.73
DiseaseR-HSA-16436853.33
Insulin receptor signalling cascadeR-HSA-747514.85
Downstream signaling of activated FGFR1R-HSA-56546874.71
PI-3K cascade:FGFR4R-HSA-56547206.37
PI-3K cascade:FGFR1R-HSA-56546896.37
Negative regulation of FGFR1 signalingR-HSA-56547267.98
Negative regulation of FGFR2 signalingR-HSA-56547277.89
Toll-Like Receptors CascadesR-HSA-1688985.91
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
PI3K/AKT Signaling in CancerR-HSA-22195286.56
Diseases of signal transductionR-HSA-56632024.89
SHC-mediated cascade:FGFR2R-HSA-56546998.28
PI-3K cascade:FGFR2R-HSA-56546956.37
Downstream signaling of activated FGFR2R-HSA-56546964.71
FRS-mediated FGFR1 signalingR-HSA-56546935.14
Interleukin-6 signalingR-HSA-10596839.52
Signaling by PDGFR-HSA-1867974.53
Activated TLR4 signallingR-HSA-1660546.27
Netrin-1 signalingR-HSA-3737527.59
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Signaling by InterleukinsR-HSA-4491474.71
PI3K events in ERBB4 signalingR-HSA-12503426.37
Cell surface interactions at the vascular wallR-HSA-2027336.32
Cytokine Signaling in Immune systemR-HSA-12802153.74
Signaling by ERBB4R-HSA-12363944.7
MAPK1/MAPK3 signalingR-HSA-56849965.11
Adaptive Immune SystemR-HSA-12802183.19
MAPK family signaling cascadesR-HSA-56830574.89
PIP3 activates AKT signalingR-HSA-12576046.37
Platelet activation, signaling and aggregationR-HSA-760025.15
Platelet sensitization by LDLR-HSA-4321428.89
Costimulation by the CD28 familyR-HSA-3888416.56
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
Signaling by FGFRR-HSA-1902364.67
Signaling by SCF-KITR-HSA-14335574.73
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
Signalling by NGFR-HSA-1665204.23
MAPK3 (ERK1) activationR-HSA-1100569.66
HemostasisR-HSA-1095823.98
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
phosphatase activityGO:00167914.11
hydrolase activityGO:00167871.9
enzyme bindingGO:00198992.27
phosphoric ester hydrolase activityGO:00425783.82
macromolecular complex bindingGO:00448772.61
bindingGO:00054880.18
phosphatidylinositol 3-kinase activityGO:00350045.49
G-protein coupled receptor bindingGO:00016644.18
phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469345.61
insulin receptor substrate bindingGO:00435607.25
receptor tyrosine kinase bindingGO:00309715.77
phosphatidylinositol bisphosphate kinase activityGO:00528135.56
transferase activityGO:00167401.95
protein complex bindingGO:00324033.09
protein tyrosine kinase bindingGO:19907825.7
SH3/SH2 adaptor activityGO:00050705.79
insulin receptor bindingGO:00051586.27
D1 dopamine receptor bindingGO:00317487.66
1-phosphatidylinositol-3-kinase activityGO:00163035.98
kinase activityGO:00163012.93
hydrolase activity, acting on ester bondsGO:00167883.1
protein kinase bindingGO:00199013.44
kinase bindingGO:00199003.32
phospholipase bindingGO:00432746.91
protein domain specific bindingGO:00199043.32
peptide hormone receptor bindingGO:00514286.91
hormone receptor bindingGO:00514274.57
binding, bridgingGO:00600904.57
protein binding, bridgingGO:00306744.68
catalytic activityGO:00038241.05
phosphatidylinositol kinase activityGO:00527425.81
non-membrane spanning protein tyrosine phosphatase activityGO:00047267.66
protein tyrosine phosphatase activityGO:00047255.09
phosphoprotein phosphatase activityGO:00047214.55
signaling adaptor activityGO:00355915.43
protein bindingGO:00055150.46
transferase activity, transferring phosphorus-containing groupsGO:00167722.77
dopamine receptor bindingGO:00507806.85
receptor bindingGO:00051022.43
phosphotransferase activity, alcohol group as acceptorGO:00167733.08