| Disease ID | Disease name | Source of annotation with RB1 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 259500 | OSTEOGENIC SARCOMA | OMIM | link to OMIM | 3 | TP53, RB1, CHEK2 |
| 182280 | SMALL CELL CANCER OF THE LUNG | ClinVar, OMIM | link to OMIM | 1 | RB1 |
| 109800 | BLADDER CANCER | OMIM | link to OMIM | 4 | FGFR3, RB1, KRAS, HRAS |
| 180200 | RETINOBLASTOMA | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | RB1 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Melanoma | hsa05218 | 6.56 |
| Bladder cancer | hsa05219 | 7.38 |
| Glioma | hsa05214 | 6.66 |
| Pancreatic cancer | hsa05212 | 6.56 |
| Cell cycle | hsa04110 | 5.68 |
| Pathways in cancer | hsa05200 | 3.98 |
| Viral carcinogenesis | hsa05203 | 5.08 |
| Prostate cancer | hsa05215 | 6.11 |
| Non-small cell lung cancer | hsa05223 | 6.88 |
| Epstein-Barr virus infection | hsa05169 | 4.97 |
| Chronic myeloid leukemia | hsa05220 | 6.48 |
| HTLV-I infection | hsa05166 | 4.59 |
| Hepatitis B | hsa05161 | 5.52 |
| Small cell lung cancer | hsa05222 | 6.17 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | R-HSA-2559584 | 8.98 |
| DNA Damage/Telomere Stress Induced Senescence | R-HSA-2559586 | 7.15 |
| Cellular Senescence | R-HSA-2559583 | 5.7 |
| Cell Cycle, Mitotic | R-HSA-69278 | 4.16 |
| Cell Cycle | R-HSA-1640170 | 3.89 |
| Switching of origins to a post-replicative state | R-HSA-69052 | 6.85 |
| Cellular responses to stress | R-HSA-2262752 | 4.56 |
| G1 Phase | R-HSA-69236 | 7.73 |
| Orc1 removal from chromatin | R-HSA-68949 | 6.85 |
| Condensation of Prophase Chromosomes | R-HSA-2299718 | 7.66 |
| Cyclin D associated events in G1 | R-HSA-69231 | 7.73 |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 | R-HSA-113501 | 9.4 |
| Synthesis of DNA | R-HSA-69239 | 6.37 |
| Mitotic G1-G1/S phases | R-HSA-453279 | 5.91 |
| M Phase | R-HSA-68886 | 4.87 |
| Cyclin A:Cdk2-associated events at S phase entry | R-HSA-69656 | 6.94 |
| G1/S Transition | R-HSA-69206 | 6.21 |
| Cyclin E associated events during G1/S transition | R-HSA-69202 | 6.96 |
| Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes | R-HSA-69200 | 10.98 |
| S Phase | R-HSA-69242 | 6.02 |
| DNA Replication | R-HSA-69306 | 6.25 |
| Regulation of DNA replication | R-HSA-69304 | 6.75 |
| Removal of licensing factors from origins | R-HSA-69300 | 6.81 |
| E2F mediated regulation of DNA replication | R-HSA-113510 | 7.94 |
| Mitotic Prophase | R-HSA-68875 | 6.27 |
| GO term | GO ID | GO IC |
|---|---|---|
| ubiquitin-like protein ligase binding | GO:0044389 | 4.15 |
| RNA polymerase II activating transcription factor binding | GO:0001102 | 6.13 |
| activating transcription factor binding | GO:0033613 | 5.68 |
| androgen receptor binding | GO:0050681 | 6.07 |
| enzyme binding | GO:0019899 | 2.27 |
| binding | GO:0005488 | 0.18 |
| nucleic acid binding | GO:0003676 | 1.44 |
| DNA binding | GO:0003677 | 1.92 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| transcription coactivator activity | GO:0003713 | 4.04 |
| transcription cofactor activity | GO:0003712 | 3.44 |
| transcription factor activity, transcription factor binding | GO:0000989 | 3.36 |
| transcription factor activity, protein binding | GO:0000988 | 3.35 |
| identical protein binding | GO:0042802 | 2.63 |
| steroid hormone receptor binding | GO:0035258 | 5.32 |
| regulatory region nucleic acid binding | GO:0001067 | 3.03 |
| transcription factor binding | GO:0008134 | 3.46 |
| nuclear hormone receptor binding | GO:0035257 | 4.7 |
| kinase binding | GO:0019900 | 3.32 |
| core promoter binding | GO:0001047 | 4.71 |
| hormone receptor binding | GO:0051427 | 4.57 |
| RNA polymerase II transcription factor binding | GO:0001085 | 5.08 |
| transcription regulatory region DNA binding | GO:0044212 | 3.03 |
| ubiquitin protein ligase binding | GO:0031625 | 4.17 |
| transcription factor activity, sequence-specific DNA binding | GO:0003700 | 2.65 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| phosphoprotein binding | GO:0051219 | 5.64 |
| protein binding | GO:0005515 | 0.46 |
| regulatory region DNA binding | GO:0000975 | 3.03 |
| receptor binding | GO:0005102 | 2.43 |
| nucleic acid binding transcription factor activity | GO:0001071 | 2.65 |