Gene table of REST : RE1 silencing transcription factor

Gene-disease associations table

Disease IDDisease nameSource of annotation with RESTOMIM linkNumber of associated genesgenes
PS194070WILMS TUMORClinVar, OMIM link to OMIM 6WT1, REST, H19, GPC3, BRCA2, POU6F2

Download the gene annotation in CSV format

Annotation of the gene REST

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways
Signaling pathways regulating pluripotency of stem cellshsa045505.6
Huntington's diseasehsa050165.17
Associated REACTOME pathways
HDACs deacetylate histonesR-HSA-32148157.08
Chromatin organizationR-HSA-48397265.19
Chromatin modifying enzymesR-HSA-32475095.19
Associated GO terms for Molecular function
potassium channel activityGO:00052674.94
cation channel activityGO:00052614.04
cation bindingGO:00431691.4
macromolecular complex bindingGO:00448772.61
nucleic acid bindingGO:00036761.44
DNA bindingGO:00036771.92
substrate-specific channel activityGO:00228383.67
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingGO:00010785.08
heterocyclic compound bindingGO:19013631.06
sequence-specific DNA bindingGO:00435652.79
sequence-specific double-stranded DNA bindingGO:19908373.2
histone deacetylase activityGO:00044076.0
transcription factor bindingGO:00081343.46
outward rectifier potassium channel activityGO:00152717.44
transmembrane transporter activityGO:00228572.82
ion bindingGO:00431671.36
voltage-gated cation channel activityGO:00228434.83
protein complex bindingGO:00324033.09
passive transmembrane transporter activityGO:00228033.6
metal ion transmembrane transporter activityGO:00468733.71
metal ion bindingGO:00468721.41
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific bindingGO:00009823.94
RNA polymerase II transcription factor activity, sequence-specific DNA bindingGO:00009813.29
hydrolase activityGO:00167871.9
deacetylase activityGO:00192135.7
voltage-gated potassium channel activityGO:00052495.24
inorganic cation transmembrane transporter activityGO:00228903.49
transporter activityGO:00052152.57
ion channel activityGO:00052163.71
cation transmembrane transporter activityGO:00083243.32
regulatory region nucleic acid bindingGO:00010673.03
catalytic activityGO:00038241.05
core promoter bindingGO:00010474.71
core promoter sequence-specific DNA bindingGO:00010465.12
double-stranded DNA bindingGO:00036903.09
substrate-specific transmembrane transporter activityGO:00228912.9
transcription regulatory region DNA bindingGO:00442123.03
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific bindingGO:00012274.61
substrate-specific transporter activityGO:00228922.72
voltage-gated ion channel activityGO:00052444.49
transcription factor activity, sequence-specific DNA bindingGO:00037002.65
organic cyclic compound bindingGO:00971591.05
hydrolase activity, acting on carbon-nitrogen (but not peptide) bondsGO:00168104.76
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidesGO:00168115.28
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingGO:00012283.98
ion transmembrane transporter activityGO:00150753.04
voltage-gated channel activityGO:00228324.49
monovalent inorganic cation transmembrane transporter activityGO:00150773.87
channel activityGO:00152673.6
transcription regulatory region sequence-specific DNA bindingGO:00009763.24
gated channel activityGO:00228363.96
protein bindingGO:00055150.46
regulatory region DNA bindingGO:00009753.03
protein deacetylase activityGO:00335585.95
chromatin bindingGO:00036823.64
potassium ion transmembrane transporter activityGO:00150794.77
nucleic acid binding transcription factor activityGO:00010712.65