Gene table of RET : ret proto-oncogene

Gene-disease associations table

Disease ID	Disease name	Source of annotation with RET	OMIM link	Number of associated genes	genes
PS142623	HIRSCHSPRUNG DISEASE	ClinVar, OMIM, HUMSAVAR	link to OMIM	21	TSC2, THBS4, PTCH1, NTF3, EDN3, AHNAK, ZHX2, GFRA1, KDR, PLAU, IRAK3, FBN1, RET, CNTN5, DPYD, GDNF, EDNRB, CREBBP, SEMA3D, FAT3, POLR2F
171300	PHEOCHROMOCYTOMA	OMIM, HUMSAVAR	link to OMIM	8	VHL, GDNF, SDHB, KIF1B, RET, MAX, TMEM127, SDHD
209880	CENTRAL HYPOVENTILATION SYNDROME, CONGENITAL	ClinVar, OMIM, HUMSAVAR	link to OMIM	6	ASCL1, BDNF, EDN3, GDNF, PHOX2B, RET
PS131100	MULTIPLE ENDOCRINE NEOPLASIA	ClinVar, OMIM, HUMSAVAR	link to OMIM	3	CDKN1B, RET, MEN1
191830	RENAL HYPODYSPLASIA/APLASIA 1	ClinVar, OMIM	link to OMIM	3	UPK3A, ITGA8, RET
155240	THYROID CARCINOMA, FAMILIAL MEDULLARY	ClinVar, OMIM, HUMSAVAR	link to OMIM	2	NTRK1, RET

Download the gene annotation in CSV format

Annotation of the gene RET

Associated genes in ENSEMBL

ENSG00000165731

Associated proteins - SwissProt Accession ID

P07949

Associated PDB IDs

Cytogenetic Band

10q11.21

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Central carbon metabolism in cancer	hsa05230	6.7
Thyroid cancer	hsa05216	7.48
Endocytosis	hsa04144	4.92
Pathways in cancer	hsa05200	3.98

Associated REACTOME pathways

Associated GO terms for Molecular function

GO term	GO ID	GO IC
Ras guanyl-nucleotide exchange factor activity	GO:0005088	4.31
signaling receptor activity	GO:0038023	2.49
purine ribonucleoside triphosphate binding	GO:0035639	2.22
guanyl-nucleotide exchange factor activity	GO:0005085	4.02
molecular transducer activity	GO:0060089	2.32
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
molecular function regulator	GO:0098772	2.51
transmembrane receptor protein tyrosine kinase activity	GO:0004714	5.55
ion binding	GO:0043167	1.36
transferase activity	GO:0016740	1.95
calcium ion binding	GO:0005509	3.17
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
protein kinase activity	GO:0004672	3.27
metal ion binding	GO:0046872	1.41
ATP binding	GO:0005524	2.43
protein tyrosine kinase activity	GO:0004713	4.54
kinase activity	GO:0016301	2.93
nucleoside phosphate binding	GO:1901265	1.96
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
transmembrane signaling receptor activity	GO:0004888	2.57
adenyl ribonucleotide binding	GO:0032559	2.41
ribonucleotide binding	GO:0032553	2.19
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
transmembrane receptor protein kinase activity	GO:0019199	5.32
purine ribonucleoside binding	GO:0032550	2.22
transmembrane receptor activity	GO:0099600	2.53
receptor activity	GO:0004872	2.32