| Disease ID | Disease name | Source of annotation with RNF135 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 614192 | MACROCEPHALY, MACROSOMIA, AND FACIAL DYSMORPHISM SYNDROME | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | RNF135 |
Download the gene annotation in CSV format
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| TRAF6 mediated NF-kB activation | R-HSA-933542 | 8.4 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | R-HSA-933543 | 9.4 |
| TRAF6 mediated IRF7 activation | R-HSA-933541 | 7.98 |
| TRAF3-dependent IRF activation pathway | R-HSA-918233 | 9.18 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Immune System | R-HSA-168256 | 2.37 |
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | R-HSA-168928 | 6.7 |
| Negative regulators of RIG-I/MDA5 signaling | R-HSA-936440 | 7.98 |
| GO term | GO ID | GO IC |
|---|---|---|
| ubiquitin-like protein transferase activity | GO:0019787 | 3.69 |
| cation binding | GO:0043169 | 1.4 |
| transition metal ion binding | GO:0046914 | 2.48 |
| ubiquitin-protein transferase activity | GO:0004842 | 3.73 |
| ion binding | GO:0043167 | 1.36 |
| catalytic activity | GO:0003824 | 1.05 |
| transferase activity | GO:0016740 | 1.95 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| ribonucleoprotein complex binding | GO:0043021 | 5.15 |
| metal ion binding | GO:0046872 | 1.41 |
| ligase activity | GO:0016874 | 3.72 |
| zinc ion binding | GO:0008270 | 2.66 |