| signaling receptor activity | GO:0038023 | 2.49 |
| nucleic acid binding | GO:0003676 | 1.44 |
| molecular transducer activity | GO:0060089 | 2.32 |
| transcription factor activity, direct ligand regulated sequence-specific DNA binding | GO:0098531 | 5.87 |
| receptor activity | GO:0004872 | 2.32 |
| signal transducer activity | GO:0004871 | 2.28 |
| DNA binding | GO:0003677 | 1.92 |
| melatonin receptor activity | GO:0008502 | 8.13 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | GO:0004879 | 5.87 |
| sequence-specific DNA binding | GO:0043565 | 2.79 |
| G-protein coupled receptor activity | GO:0004930 | 2.95 |
| transition metal ion binding | GO:0046914 | 2.48 |
| zinc ion binding | GO:0008270 | 2.66 |
| ion binding | GO:0043167 | 1.36 |
| metal ion binding | GO:0046872 | 1.41 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | GO:0000981 | 3.29 |
| cation binding | GO:0043169 | 1.4 |
| transcription factor binding | GO:0008134 | 3.46 |
| transcription factor activity, sequence-specific DNA binding | GO:0003700 | 2.65 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| nucleic acid binding transcription factor activity | GO:0001071 | 2.65 |
| steroid hormone receptor activity | GO:0003707 | 5.66 |
| transmembrane signaling receptor activity | GO:0004888 | 2.57 |
| protein binding | GO:0005515 | 0.46 |
| transmembrane receptor activity | GO:0099600 | 2.53 |
| binding | GO:0005488 | 0.18 |