Gene table of RRM2B : ribonucleotide reductase regulatory TP53 inducible subunit M2B

Gene-disease associations table

Disease IDDisease nameSource of annotation with RRM2BOMIM linkNumber of associated genesgenes
PS603041MITOCHONDRIAL DNA DEPLETION SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 14RRM2B, SLC25A4, AGK, C10orf2, FBXL4, SUCLG1, MGME1, POLG, MPV17, TK2, SUCLA2, DGUOK, OPA1, TYMP
PS157640PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MTDNA DELETIONSClinVar, OMIM link to OMIM 7SLC25A4, DNA2, C10orf2, RRM2B, RNASEH1, POLG, POLG2

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Annotation of the gene RRM2B

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Metabolic pathwayshsa011002.49
p53 signaling pathwayhsa041156.56
Glutathione metabolismhsa004806.96
Pyrimidine metabolismhsa002406.01
Purine metabolismhsa002305.28
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Transcriptional Regulation by TP53R-HSA-37009896.73
Generic Transcription PathwayR-HSA-2124363.86
Gene ExpressionR-HSA-741602.72
Metabolism of nucleotidesR-HSA-158696.7
MetabolismR-HSA-14307282.34
TP53 Regulates Metabolic GenesR-HSA-56288976.73
Synthesis and interconversion of nucleotide di- and triphosphatesR-HSA-4999438.81
Associated GO terms for Molecular function
GO termGO IDGO IC
cation bindingGO:00431691.4
oxidoreductase activity, acting on CH or CH2 groupsGO:00167257.44
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptorGO:00047488.64
oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptorGO:00167288.64
ribonucleoside-diphosphate reductase activityGO:00617318.64
ion bindingGO:00431671.36
catalytic activityGO:00038241.05
bindingGO:00054880.18
protein bindingGO:00055150.46
metal ion bindingGO:00468721.41
oxidoreductase activityGO:00164913.12