| Disease ID | Disease name | Source of annotation with SERPINE1 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 613329 | PLASMINOGEN ACTIVATOR INHIBITOR-1 DEFICIENCY | ClinVar, OMIM | link to OMIM | 1 | SERPINE1 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| HIF-1 signaling pathway | hsa04066 | 5.9 |
| Chagas disease (American trypanosomiasis) | hsa05142 | 5.99 |
| Hippo signaling pathway | hsa04390 | 5.37 |
| Complement and coagulation cascades | hsa04610 | 6.58 |
| p53 signaling pathway | hsa04115 | 6.56 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Circadian Clock | R-HSA-400253 | 7.03 |
| Dissolution of Fibrin Clot | R-HSA-75205 | 9.28 |
| Platelet degranulation | R-HSA-114608 | 6.68 |
| Generic Transcription Pathway | R-HSA-212436 | 3.86 |
| Gene Expression | R-HSA-74160 | 2.72 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 5.15 |
| Signaling by TGF-beta Receptor Complex | R-HSA-170834 | 6.81 |
| Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 6.59 |
| ECM proteoglycans | R-HSA-3000178 | 6.75 |
| Extracellular matrix organization | R-HSA-1474244 | 4.91 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | R-HSA-2173793 | 7.56 |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | R-HSA-1368108 | 7.59 |
| Hemostasis | R-HSA-109582 | 3.98 |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | R-HSA-2173796 | 8.03 |
| GO term | GO ID | GO IC |
|---|---|---|
| endopeptidase inhibitor activity | GO:0004866 | 4.6 |
| peptidase inhibitor activity | GO:0030414 | 4.55 |
| enzyme regulator activity | GO:0030234 | 2.85 |
| peptidase regulator activity | GO:0061134 | 4.37 |
| enzyme binding | GO:0019899 | 2.27 |
| endopeptidase regulator activity | GO:0061135 | 4.57 |
| protease binding | GO:0002020 | 5.08 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| serine-type endopeptidase inhibitor activity | GO:0004867 | 5.16 |
| receptor binding | GO:0005102 | 2.43 |
| molecular function regulator | GO:0098772 | 2.51 |
| enzyme inhibitor activity | GO:0004857 | 3.78 |