Disease ID | Disease name | Source of annotation with SLC2A4 | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
125853 | DIABETES MELLITUS, NONINSULIN-DEPENDENT | ClinVar, HUMSAVAR | link to OMIM | 33 | SLC2A2, HNF4A, TCF7L2, SLC30A8, GPD2, PAX4, PTPN1, SLC2A4, ABCC8, HMGA1, LIPC, NEUROD1, CDKAL1, WFS1, PPARG, RETN, AKT2, IRS2, IL6, IRS1, GCGR, CAPN10, IGF2BP2, INSR, PDX1, MTNR1B, GCK, HNF1B, HNF1A, MAPK8IP1, ENPP1, PPP1R3A, KCNJ11 |
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KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
Type II diabetes mellitus | hsa04930 | 7.12 |
Insulin signaling pathway | hsa04910 | 5.55 |
AMPK signaling pathway | hsa04152 | 5.8 |
FoxO signaling pathway | hsa04068 | 5.63 |
Adipocytokine signaling pathway | hsa04920 | 6.6 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
Facilitative Na+-independent glucose transporters | R-HSA-428790 | 9.28 |
Membrane Trafficking | R-HSA-199991 | 5.26 |
Metabolism of carbohydrates | R-HSA-71387 | 4.93 |
Transcriptional regulation of white adipocyte differentiation | R-HSA-381340 | 6.7 |
Transmembrane transport of small molecules | R-HSA-382551 | 3.79 |
Hexose transport | R-HSA-189200 | 7.43 |
Metabolism | R-HSA-1430728 | 2.34 |
SLC-mediated transmembrane transport | R-HSA-425407 | 4.95 |
Translocation of GLUT4 to the plasma membrane | R-HSA-1445148 | 6.77 |
Glucose transport | R-HSA-70153 | 7.62 |
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | R-HSA-425366 | 6.34 |
Developmental Biology | R-HSA-1266738 | 3.48 |
Vesicle-mediated transport | R-HSA-5653656 | 4.33 |
GO term | GO ID | GO IC |
---|---|---|
substrate-specific transmembrane transporter activity | GO:0022891 | 2.9 |
glucose transmembrane transporter activity | GO:0005355 | 6.85 |
substrate-specific transporter activity | GO:0022892 | 2.72 |
sugar transmembrane transporter activity | GO:0051119 | 6.3 |
carbohydrate transporter activity | GO:1901476 | 5.95 |
transporter activity | GO:0005215 | 2.57 |
D-glucose transmembrane transporter activity | GO:0055056 | 7.66 |
hexose transmembrane transporter activity | GO:0015149 | 6.79 |
transmembrane transporter activity | GO:0022857 | 2.82 |
binding | GO:0005488 | 0.18 |
protein binding | GO:0005515 | 0.46 |
monosaccharide transmembrane transporter activity | GO:0015145 | 6.79 |
carbohydrate transmembrane transporter activity | GO:0015144 | 5.95 |