Gene table of SMAD7 : SMAD family member 7

Gene-disease associations table

Disease ID	Disease name	Source of annotation with SMAD7	OMIM link	Number of associated genes	genes
612229	COLORECTAL CANCER, SUSCEPTIBILITY TO, 3	ClinVar, OMIM	link to OMIM	1	SMAD7

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Generic Transcription Pathway	R-HSA-212436	3.86
Gene Expression	R-HSA-74160	2.72
Signaling by TGF-beta Receptor Complex	R-HSA-170834	6.81
Signal Transduction	R-HSA-162582	1.78
TGF-beta receptor signaling activates SMADs	R-HSA-2173789	7.98
Downregulation of TGF-beta receptor signaling	R-HSA-2173788	8.28
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	R-HSA-2173793	7.56
Signaling by BMP	R-HSA-201451	8.46
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	R-HSA-2173796	8.03

Associated GO terms for Molecular function

GO term	GO ID	GO IC
cytokine receptor binding	GO:0005126	4.14
ubiquitin-like protein ligase binding	GO:0044389	4.15
nucleic acid binding	GO:0003676	1.44
transforming growth factor beta receptor binding	GO:0005160	5.81
enzyme binding	GO:0019899	2.27
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
DNA binding	GO:0003677	1.92
heterocyclic compound binding	GO:1901363	1.06
cation binding	GO:0043169	1.4
transforming growth factor beta receptor, cytoplasmic mediator activity	GO:0005072	7.44
receptor signaling protein activity	GO:0005057	4.76
ion binding	GO:0043167	1.36
I-SMAD binding	GO:0070411	7.34
protein complex binding	GO:0032403	3.09
metal ion binding	GO:0046872	1.41
regulatory region nucleic acid binding	GO:0001067	3.03
beta-catenin binding	GO:0008013	5.3
SMAD binding	GO:0046332	5.45
type I transforming growth factor beta receptor binding	GO:0034713	7.44
transcription regulatory region DNA binding	GO:0044212	3.03
ubiquitin protein ligase binding	GO:0031625	4.17
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
organic cyclic compound binding	GO:0097159	1.05
transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity	GO:0030617	9.05
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
receptor binding	GO:0005102	2.43
collagen binding	GO:0005518	5.58
activin binding	GO:0048185	7.25
nucleic acid binding transcription factor activity	GO:0001071	2.65