Gene table of SMAD7 : SMAD family member 7

Gene-disease associations table

Disease IDDisease nameSource of annotation with SMAD7OMIM linkNumber of associated genesgenes
612229COLORECTAL CANCER, SUSCEPTIBILITY TO, 3ClinVar, OMIM link to OMIM 1SMAD7

Download the gene annotation in CSV format

Annotation of the gene SMAD7

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
TGF-beta signaling pathwayhsa043506.41
Hippo signaling pathwayhsa043905.37
Endocytosishsa041444.92
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Generic Transcription PathwayR-HSA-2124363.86
Gene ExpressionR-HSA-741602.72
Signaling by TGF-beta Receptor ComplexR-HSA-1708346.81
Signal TransductionR-HSA-1625821.78
TGF-beta receptor signaling activates SMADsR-HSA-21737897.98
Downregulation of TGF-beta receptor signalingR-HSA-21737888.28
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerR-HSA-21737937.56
Signaling by BMPR-HSA-2014518.46
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionR-HSA-21737968.03
Associated GO terms for Molecular function
GO termGO IDGO IC
cytokine receptor bindingGO:00051264.14
ubiquitin-like protein ligase bindingGO:00443894.15
nucleic acid bindingGO:00036761.44
transforming growth factor beta receptor bindingGO:00051605.81
enzyme bindingGO:00198992.27
macromolecular complex bindingGO:00448772.61
bindingGO:00054880.18
signal transducer activityGO:00048712.28
DNA bindingGO:00036771.92
heterocyclic compound bindingGO:19013631.06
cation bindingGO:00431691.4
transforming growth factor beta receptor, cytoplasmic mediator activityGO:00050727.44
receptor signaling protein activityGO:00050574.76
ion bindingGO:00431671.36
I-SMAD bindingGO:00704117.34
protein complex bindingGO:00324033.09
metal ion bindingGO:00468721.41
regulatory region nucleic acid bindingGO:00010673.03
beta-catenin bindingGO:00080135.3
SMAD bindingGO:00463325.45
type I transforming growth factor beta receptor bindingGO:00347137.44
transcription regulatory region DNA bindingGO:00442123.03
ubiquitin protein ligase bindingGO:00316254.17
transcription factor activity, sequence-specific DNA bindingGO:00037002.65
organic cyclic compound bindingGO:00971591.05
transforming growth factor beta receptor, inhibitory cytoplasmic mediator activityGO:00306179.05
protein bindingGO:00055150.46
regulatory region DNA bindingGO:00009753.03
receptor bindingGO:00051022.43
collagen bindingGO:00055185.58
activin bindingGO:00481857.25
nucleic acid binding transcription factor activityGO:00010712.65