Gene table of SMO : smoothened, frizzled class receptor

Gene-disease associations table

Disease ID	Disease name	Source of annotation with SMO	OMIM link	Number of associated genes	genes
605462	BASAL CELL CARCINOMA, SUSCEPTIBILITY TO, 1	OMIM	link to OMIM	4	RASA1, PTCH2, PTCH1, SMO

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Class B/2 (Secretin family receptors)	R-HSA-373080	6.52
GPCR ligand binding	R-HSA-500792	4.19
Hedgehog 'off' state	R-HSA-5610787	6.19
Signaling by GPCR	R-HSA-372790	2.68
Organelle biogenesis and maintenance	R-HSA-1852241	4.63
Hedgehog 'on' state	R-HSA-5632684	6.62
Signaling by Hedgehog	R-HSA-5358351	5.79
Cargo trafficking to the periciliary membrane	R-HSA-5620920	7.31
Assembly of the primary cilium	R-HSA-5617833	5.44
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	8.46
Activation of SMO	R-HSA-5635838	9.66
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
G-protein coupled receptor activity	GO:0004930	2.95
signaling receptor activity	GO:0038023	2.49
protein binding	GO:0005515	0.46
drug binding	GO:0008144	5.03
Wnt-activated receptor activity	GO:0042813	6.65
molecular transducer activity	GO:0060089	2.32
transmembrane signaling receptor activity	GO:0004888	2.57
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
Wnt-protein binding	GO:0017147	6.3
receptor binding	GO:0005102	2.43
patched binding	GO:0005113	7.66
transmembrane receptor activity	GO:0099600	2.53
receptor activity	GO:0004872	2.32