| Disease ID | Disease name | Source of annotation with STK11 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS155600 | MELANOMA, CUTANEOUS MALIGNANT | ClinVar, OMIM | link to OMIM | 11 | STK11, POT1, BRAF, TERT, PTEN, CDKN2A, MITF, TYR, MC1R, CDK4, XRCC3 |
| 260350 | PANCREATIC CANCER | ClinVar, OMIM | link to OMIM | 6 | STK11, KRAS, ACVR1B, RBBP8, SMAD4, TP53 |
| 273300 | TESTICULAR GERM CELL TUMOR | ClinVar, OMIM, HUMSAVAR | link to OMIM | 5 | STK11, BCL10, KIT, FGFR3, STK10 |
| 175200 | PEUTZ-JEGHERS SYNDROME | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | STK11 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Adipocytokine signaling pathway | hsa04920 | 6.6 |
| AMPK signaling pathway | hsa04152 | 5.8 |
| mTOR signaling pathway | hsa04150 | 6.72 |
| FoxO signaling pathway | hsa04068 | 5.63 |
| PI3K-Akt signaling pathway | hsa04151 | 4.21 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 4.85 |
| Energy dependent regulation of mTOR by LKB1-AMPK | R-HSA-380972 | 8.18 |
| AMPK inhibits chREBP transcriptional activation activity | R-HSA-163680 | 10.66 |
| Integration of energy metabolism | R-HSA-163685 | 6.24 |
| IRS-mediated signalling | R-HSA-112399 | 4.87 |
| PI3K Cascade | R-HSA-109704 | 6.68 |
| IGF1R signaling cascade | R-HSA-2428924 | 4.85 |
| PKB-mediated events | R-HSA-109703 | 7.66 |
| IRS-related events triggered by IGF1R | R-HSA-2428928 | 4.85 |
| Metabolism | R-HSA-1430728 | 2.34 |
| mTOR signalling | R-HSA-165159 | 7.7 |
| Signaling by Insulin receptor | R-HSA-74752 | 4.73 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| Insulin receptor signalling cascade | R-HSA-74751 | 4.85 |
| GO term | GO ID | GO IC |
|---|---|---|
| kinase regulator activity | GO:0019207 | 4.5 |
| purine ribonucleoside triphosphate binding | GO:0035639 | 2.22 |
| kinase activator activity | GO:0019209 | 5.58 |
| binding | GO:0005488 | 0.18 |
| nucleotide binding | GO:0000166 | 1.96 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| purine nucleoside binding | GO:0001883 | 2.22 |
| nucleoside binding | GO:0001882 | 2.21 |
| cation binding | GO:0043169 | 1.4 |
| molecular function regulator | GO:0098772 | 2.51 |
| magnesium ion binding | GO:0000287 | 4.41 |
| ion binding | GO:0043167 | 1.36 |
| protein serine/threonine kinase activity | GO:0004674 | 3.64 |
| transferase activity | GO:0016740 | 1.95 |
| nucleoside phosphate binding | GO:1901265 | 1.96 |
| ribonucleoside binding | GO:0032549 | 2.22 |
| purine nucleotide binding | GO:0017076 | 2.19 |
| protein kinase activity | GO:0004672 | 3.27 |
| metal ion binding | GO:0046872 | 1.41 |
| ATP binding | GO:0005524 | 2.43 |
| protein kinase regulator activity | GO:0019887 | 4.6 |
| enzyme regulator activity | GO:0030234 | 2.85 |
| kinase activity | GO:0016301 | 2.93 |
| small molecule binding | GO:0036094 | 1.89 |
| catalytic activity | GO:0003824 | 1.05 |
| protein domain specific binding | GO:0019904 | 3.32 |
| LRR domain binding | GO:0030275 | 6.91 |
| protein kinase activator activity | GO:0030295 | 5.68 |
| adenyl nucleotide binding | GO:0030554 | 2.4 |
| carbohydrate derivative binding | GO:0097367 | 2.03 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| phosphotransferase activity, alcohol group as acceptor | GO:0016773 | 3.08 |
| adenyl ribonucleotide binding | GO:0032559 | 2.41 |
| protein binding | GO:0005515 | 0.46 |
| transferase activity, transferring phosphorus-containing groups | GO:0016772 | 2.77 |
| purine ribonucleotide binding | GO:0032555 | 2.2 |
| p53 binding | GO:0002039 | 5.53 |
| purine ribonucleoside binding | GO:0032550 | 2.22 |
| ribonucleotide binding | GO:0032553 | 2.19 |
| enzyme activator activity | GO:0008047 | 3.56 |