Gene table of TAP1 : transporter 1, ATP binding cassette subfamily B member

Gene-disease associations table

Disease ID	Disease name	Source of annotation with TAP1	OMIM link	Number of associated genes	genes
604571	BARE LYMPHOCYTE SYNDROME, TYPE I	ClinVar, OMIM	link to OMIM	3	TAP1, TAP2, TAPBP

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Annotation of the gene TAP1

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Q03518

Associated PDB IDs

1jj7

Cytogenetic Band

6p21.32

Tandem repeats annotation

The gene is in the tandem Group 293, together with the genes:

TAP2

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Primary immunodeficiency	hsa05340	7.52
ABC transporters	hsa02010	7.28
Herpes simplex infection	hsa05168	5.08
Phagosome	hsa04145	5.27
Antigen processing and presentation	hsa04612	6.04

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Immune System	R-HSA-168256	2.37
Antigen processing-Cross presentation	R-HSA-1236975	5.88
ER-Phagosome pathway	R-HSA-1236974	6.08
Class I MHC mediated antigen processing & presentation	R-HSA-983169	4.65
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	R-HSA-983170	6.64
Adaptive Immune System	R-HSA-1280218	3.19

Associated GO terms for Molecular function

GO term	GO ID	GO IC
ADP binding	GO:0043531	6.24
purine ribonucleoside triphosphate binding	GO:0035639	2.22
peptide-transporting ATPase activity	GO:0015440	8.13
binding	GO:0005488	0.18
ATPase activity	GO:0016887	3.65
TAP binding	GO:0046977	7.79
TAP1 binding	GO:0046978	8.35
TAP2 binding	GO:0046979	8.64
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
ATPase activity, coupled to transmembrane movement of substances	GO:0042626	5.06
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	GO:0016820	5.03
peptide binding	GO:0042277	4.22
peptide antigen binding	GO:0042605	6.18
nucleotide binding	GO:0000166	1.96
primary active transmembrane transporter activity	GO:0015399	4.98
identical protein binding	GO:0042802	2.63
purine nucleoside binding	GO:0001883	2.22
transporter activity	GO:0005215	2.57
purine nucleotide binding	GO:0017076	2.19
active transmembrane transporter activity	GO:0022804	3.85
protein homodimerization activity	GO:0042803	3.16
hydrolase activity	GO:0016787	1.9
MHC class I protein binding	GO:0042288	6.85
amide binding	GO:0033218	4.14
ribonucleoside binding	GO:0032549	2.22
nucleoside-triphosphatase activity	GO:0017111	3.09
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
antigen binding	GO:0003823	5.02
peptide transporter activity	GO:0015197	7.44
MHC class Ib protein binding	GO:0023029	8.35
protein dimerization activity	GO:0046983	2.72
MHC protein binding	GO:0042287	6.18
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO:0016818	3.03
substrate-specific transporter activity	GO:0022892	2.72
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
ATPase activity, coupled to movement of substances	GO:0043492	4.93
ATPase activity, coupled	GO:0042623	3.97
hydrolase activity, acting on acid anhydrides	GO:0016817	3.03
purine ribonucleoside binding	GO:0032550	2.22
pyrophosphatase activity	GO:0016462	3.04
transmembrane transporter activity	GO:0022857	2.82
adenyl ribonucleotide binding	GO:0032559	2.41
ATP binding	GO:0005524	2.43
protein binding	GO:0005515	0.46
purine ribonucleotide binding	GO:0032555	2.2
tapasin binding	GO:0046980	9.05
receptor binding	GO:0005102	2.43
protein heterodimerization activity	GO:0046982	3.64
P-P-bond-hydrolysis-driven transmembrane transporter activity	GO:0015405	4.98
ribonucleotide binding	GO:0032553	2.19